TY - JOUR
T1 - Adoptive immunotherapy of human cancer
T2 - The cytokine cascade and monocyte activation following high-dose interleukin 2 bolus treatment
AU - Boccoli, G.
AU - Masciulli, R.
AU - Ruggeri, E. M.
AU - Carlini, P.
AU - Giannella, G.
AU - Montesoro, E.
AU - Mastroberardino, G.
AU - Isacchi, G.
AU - Testa, U.
AU - Calabresi, F.
AU - Peschle, C.
PY - 1990/9/15
Y1 - 1990/9/15
N2 - Serum concentration kinetics of γ-interferon (IFN-γ), neopterin, 2′-5′A synthetase and tumor necrosis factor a were determined in five cancer patients undergoing adoptive immunotherapy with high-dose interleukin 2 (IL-2) bolus infusion and lymphokine-activated killer cells according to the National Cancer Institute, NIH protocol. In all cases a significant increase of these markers was observed after IL-2 treatment. This suggests that the antitumor effect of high-dose IL-2 bolus administration may be in part mediated by activation of a cascade of endogenous cytokines including IFN-γ and tumor necrosis factor α. After IL-2 bolus injection, the kinetics of neopterin was similar but delayed when compared to that of IFN-γ: this suggests that macrophages, the specific source of neopterin, become activated by IFN-γ following IL-2-mediated lymphocyte induction, thus implying a possible role for macrophages in the antitumor effects mediated by IL-2 and lymphokine-activated killer cells.
AB - Serum concentration kinetics of γ-interferon (IFN-γ), neopterin, 2′-5′A synthetase and tumor necrosis factor a were determined in five cancer patients undergoing adoptive immunotherapy with high-dose interleukin 2 (IL-2) bolus infusion and lymphokine-activated killer cells according to the National Cancer Institute, NIH protocol. In all cases a significant increase of these markers was observed after IL-2 treatment. This suggests that the antitumor effect of high-dose IL-2 bolus administration may be in part mediated by activation of a cascade of endogenous cytokines including IFN-γ and tumor necrosis factor α. After IL-2 bolus injection, the kinetics of neopterin was similar but delayed when compared to that of IFN-γ: this suggests that macrophages, the specific source of neopterin, become activated by IFN-γ following IL-2-mediated lymphocyte induction, thus implying a possible role for macrophages in the antitumor effects mediated by IL-2 and lymphokine-activated killer cells.
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M3 - Article
C2 - 2118421
AN - SCOPUS:0025054144
SN - 0008-5472
VL - 50
SP - 5795
EP - 5800
JO - Journal of Cancer Research
JF - Journal of Cancer Research
IS - 18
ER -