Adjunct agents for bleeding

Massimo Franchini, Pier Mannuccio Mannucci

Research output: Contribution to journalArticlepeer-review


Purpose of review This review provides a summary of the most recent clinical trials evaluating the hemostatic agents for the treatment of coagulopathy associated with critical bleeding. In particular, antifibrinolytic agents (i.e., aprotinin, tranexamic and e-aminocaproic acids), desmopressin, recombinant activated factor VII, fibrinogen and prothrombin complex concentrates are evaluated. Recent findings Among the various therapeutic options available, tranexamic acid is emerging as the most promising. Indeed, a recent randomized trial has shown a benefit survival of the early administration of tranexamic acid in patients with trauma-induced coagulopathy. Summary Although preliminary data document a potential therapeutic role for prohemostatic pharmacologic approaches, further evidence arising from randomized controlled trials is needed to assess the safety and efficacy of such agents in the setting of critical bleeding.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalCurrent Opinion in Hematology
Issue number6
Publication statusPublished - 2014


  • Antifibrinolytic agents
  • Bleeding
  • Fibrinogen
  • Prothrombin complex concentrate
  • Recombinant activated factor VII

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)


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