TY - JOUR
T1 - Adhesion molecules expression in noncrescentic acute post-streptococcal glomerulonephritis
AU - Rastaldi, Maria Pia
AU - Ferrario, Franco
AU - Yang, Lin
AU - Tunesi, Stefania
AU - Indaco, Antonio
AU - Zou, Hequn
AU - D'Amico, Giuseppe
PY - 1996/11
Y1 - 1996/11
N2 - Clinicomorphological features of 11 cases of non-crescentic acute post- streptococcal glomerulonephritis (APSGN) were reviewed. Intraglomerular and interstitial leukocytes and their possible correlation with the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial-leukocyte adhesion molecule-1 (ELAM- 1/E-selectin) were investigated by an immunohistochemical method. Intraglomerular leukocytes were primarily granulocytes (11.4 ± 10 cells/glomerular cross-section) and monocytes-macrophages (13.4 ± 19.4 cells/glomerular cross-section). The granulocytes outnumbered monocytes- macrophages in 7 of 11 specimens. The number of intraglomerular leukocytes correlated with protein-uria at the time of renal biopsy. Intraglomerular ICAM-1 staining was strongly positive in all biopsies, especially when intraglomerular monocytes-macrophages prevailed. Expression of intraglomerular VCAM-1 and E-selectin in diseased kidneys did not differ from that in normal kidneys. Interstitial leukocytes were primarily monocytes- macrophages (158.9 ± 96.8 cells/mm2) and T lymphocytes (102.2 ± 63.9 cells/mm2). The number of interstitial leukocytes, especially monocytes- macrophages, correlated with serum creatinine level at the time of biopsy. Interstitial ICAM-1 staining was strongly positive on tubules, peritubular capillaries, and small vessels. The tubular positivity for ICAM-1 correlated with the number of interstitial monocytes-macrophages. Interstitial VCAM-1 and E-selectin were expressed as in normal kidney tissues. The data from this study demonstrate that APSGN is characterized by the presence of both intraglomerular and interstitial leukocyte infiltration, correlating respectively with proteinuria and serum creatinine at the time of renal biopsy. Among the adhesion molecules studied, ICAM-1 seems the most involved in leukocyte recruitment, especially in that of monocytes-macrophages.
AB - Clinicomorphological features of 11 cases of non-crescentic acute post- streptococcal glomerulonephritis (APSGN) were reviewed. Intraglomerular and interstitial leukocytes and their possible correlation with the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial-leukocyte adhesion molecule-1 (ELAM- 1/E-selectin) were investigated by an immunohistochemical method. Intraglomerular leukocytes were primarily granulocytes (11.4 ± 10 cells/glomerular cross-section) and monocytes-macrophages (13.4 ± 19.4 cells/glomerular cross-section). The granulocytes outnumbered monocytes- macrophages in 7 of 11 specimens. The number of intraglomerular leukocytes correlated with protein-uria at the time of renal biopsy. Intraglomerular ICAM-1 staining was strongly positive in all biopsies, especially when intraglomerular monocytes-macrophages prevailed. Expression of intraglomerular VCAM-1 and E-selectin in diseased kidneys did not differ from that in normal kidneys. Interstitial leukocytes were primarily monocytes- macrophages (158.9 ± 96.8 cells/mm2) and T lymphocytes (102.2 ± 63.9 cells/mm2). The number of interstitial leukocytes, especially monocytes- macrophages, correlated with serum creatinine level at the time of biopsy. Interstitial ICAM-1 staining was strongly positive on tubules, peritubular capillaries, and small vessels. The tubular positivity for ICAM-1 correlated with the number of interstitial monocytes-macrophages. Interstitial VCAM-1 and E-selectin were expressed as in normal kidney tissues. The data from this study demonstrate that APSGN is characterized by the presence of both intraglomerular and interstitial leukocyte infiltration, correlating respectively with proteinuria and serum creatinine at the time of renal biopsy. Among the adhesion molecules studied, ICAM-1 seems the most involved in leukocyte recruitment, especially in that of monocytes-macrophages.
KW - Acute post- streptococcal glomerulonephritis
KW - E-selectin
KW - ICAM-1
KW - Leukocyte infiltration
KW - VCAM-1
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M3 - Article
C2 - 8959635
AN - SCOPUS:0030368531
SN - 1046-6673
VL - 7
SP - 2419
EP - 2427
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
IS - 11
ER -