@article{d65a447bb0554c5cb2058b8e7d346a0a,
title = "Adherence to dietary recommendations after one year of intervention in breast cancer women: The diana-5 trial",
abstract = "The Diet and Androgen-5 (DIANA-5) trial aimed at testing whether a dietary change based on the Mediterranean diet and on macrobiotic principles can reduce the incidence of breast cancer (BC)-related events. We analyzed the adherence to the DIANA-5 dietary recommendations by randomization group after 1 year of intervention. We evaluated the association between dietary adherence and changes in body weight and metabolic syndrome (MS) parameters. BC women aged 35–70 years were eligible. After the baseline examinations, women were randomized into an intervention group (IG) or a control group (CG). A total of 1344 BC women (689 IG and 655 CG) concluded the first year of dietary intervention. IG showed greater anthropometric and metabolic improvements compared to CG. These changes were significantly associated with increased adherence to the dietary recommendations. Women who increased recommended foods consumption or reduced discouraged foods consumption showed an Odds Ratio (OR) of 1.37 (0.70–2.67) and 2.02 (1.03–3.98) to improve three or more MS parameters. Moreover, women in the higher category of dietary change showed a four times higher OR of reducing body weight compared to the lower category (p < 0.001). The DIANA-5 dietary intervention is effective in reducing body weight and MS parameters.",
keywords = "Adherence to diet, DIANA-5, Weight and metabolic syndrome improvement",
author = "Eleonora Bruno and Vittorio Krogh and Giuliana Gargano and Sara Grioni and Manuela Bellegotti and Elisabetta Venturelli and Salvatore Panico and {de Magistris}, {Maria Santucci} and Bernardo Bonanni and Emanuela Zagallo and Angelica Mercandino and Bassi, {Maria Chiara} and Rosalba Amodio and Maurizio Zarcone and Rocco Galasso and Maggiorino Barbero and Milena Simeoni and Mano, {Maria Piera} and Franco Berrino and Anna Villarini and Patrizia Pasanisi",
note = "Funding Information: Italian Department of Health, Programma Integrato Oncologia (PIO, RFPS-2006?1-339715), Associazione Italiana per la Ricerca sul Cancro (AIRC, IG-2011-11942). The authors give special thanks to Cristina Gavazza (LILT Asti), Patrizia Curtosi, Claudio Lanfranco, Rita Carretto, Dina Calosso, Vicki Rabino, Tania Cunzolo, M. Luisa Amerio, Daniela Piccillo, Annalisa Alessiato, Stefania Sterpetti, Raffaella Ravera, and Simona Feira for contri-bution in recruitment activities. We thank Cristina Piccarolo, Antonella Maule, and Angela Angarano for the lifestyle activities. We thank Adalberto Cavalleri for the support in the biological bank. We also thank Maria Grazia Guerrini for the editorial support and Maria Teresa Penci for English editing. Finally, the authors would like to acknowledge, with much appreciation, all the volunteers who participate in the study. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = sep,
doi = "10.3390/nu13092990",
language = "English",
volume = "13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "NLM (Medline)",
number = "9",
}