Adherence in children with growth hormone deficiency treated with r-hGH and the easypod™ device

S. Loche, M. Salerno, P. Garofalo, G. M. Cardinale, Mr Licenziati, G. Citro, M. Caruso Nicoletti, M. Cappa, S. Longobardi, M. Maghnie, R. Perrone

Research output: Contribution to journalArticlepeer-review


Purpose: Poor adherence to recombinant human growth hormone (r-hGH) therapy is associated with reduced growth velocity in children with growth hormone deficiency (GHD). This twelve-month observational study was to assess adherence in r-hGH patients treated with the easypod, an electronic, fully automated injection device designed to track the time, date and dose administered. Methods: Ninety-seven prepubertal patients receiving r-hGH therapy were included in the study from ten Italian clinical sites and 88 completed the study. To avoid possible confounding effects, only GHD patients (79/88; 89.7 % of the overall study population) were considered in the final analysis. The primary endpoint—adherence to treatment—was calculated as the proportion of injections correctly administered during the observational period out of the expected total number of injections. The relevant information, tracked by the easypod, was collected at months 6 (V1) and 12 (V2) after baseline (V0). At study termination, adherence data were partially available from 16 patients and fully available from 53 patients. As secondary endpoints, serum IGF-1 levels, fasting serum glucose and insulin levels and key anthropometric characteristics (height, waist circumference and BMI) were also determined. Results: The easypod data showed that 56.7 % of the patients were considered to be fully (≥92 %) adherent to their treatment throughout the period V0–V2. Treatment improved stature, significantly increased IGF-1 and produced a non-significant increase in blood glucose and insulin levels. Conclusions: The injection-recording system and other characteristics of easypod could enhance the ability of physicians to monitor adherence to r-hGH treatment.

Original languageEnglish
Pages (from-to)1419-1424
Number of pages6
JournalJournal of Endocrinological Investigation
Issue number12
Publication statusPublished - Dec 1 2016

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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