TY - JOUR
T1 - Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium
AU - Arosio, Beatrice
AU - Perlini, Stefano
AU - Calabresi, Carmen
AU - Tozzi, Rossana
AU - Palladini, Giuseppina
AU - Ferrari, Alberto U.
AU - Vergani, Carlo
AU - Annoni, Giorgio
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ischemia and reperfusion injury, through activation of its receptors type 1 (A1) and 2A (A2A). Since ageing involves a complex change in these effects, we evaluated A1 and A2A gene expression in left (LV) and right ventricle (RV) from 2-, 5-, 12-, and 21-month-old Sprague-Dawley rats. LV end-diastolic (EDD) and end-systolic (ESD) internal dimensions (mm) and LV fractional shortening (FS, %) were measured by M-mode echocardiography. Senescence was associated with a reduction in FS (42±1, 38±2, 39±2 and 35±2, in 2-, 5-, 12- and 21-month-old rats; p1 mRNA levels were highest in 12 and 21-month-old animals in both ventricles (LV: p2A gene expression was lower in the aged LV (p1 receptor mRNA may partially explain the stronger antiadrenergic effects of Ado in the senescent heart.
AB - Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ischemia and reperfusion injury, through activation of its receptors type 1 (A1) and 2A (A2A). Since ageing involves a complex change in these effects, we evaluated A1 and A2A gene expression in left (LV) and right ventricle (RV) from 2-, 5-, 12-, and 21-month-old Sprague-Dawley rats. LV end-diastolic (EDD) and end-systolic (ESD) internal dimensions (mm) and LV fractional shortening (FS, %) were measured by M-mode echocardiography. Senescence was associated with a reduction in FS (42±1, 38±2, 39±2 and 35±2, in 2-, 5-, 12- and 21-month-old rats; p1 mRNA levels were highest in 12 and 21-month-old animals in both ventricles (LV: p2A gene expression was lower in the aged LV (p1 receptor mRNA may partially explain the stronger antiadrenergic effects of Ado in the senescent heart.
KW - Adenosine receptor
KW - Ageing
KW - Animal model
KW - Gene expression
KW - Heart
UR - http://www.scopus.com/inward/record.url?scp=0042206656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042206656&partnerID=8YFLogxK
U2 - 10.1016/S0531-5565(03)00095-0
DO - 10.1016/S0531-5565(03)00095-0
M3 - Article
C2 - 12915207
AN - SCOPUS:0042206656
SN - 0531-5565
VL - 38
SP - 855
EP - 861
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 8
ER -