TY - JOUR
T1 - Adaptive support ventilation versus conventional ventilation for total ventilatory support in acute respiratory failure
AU - Iotti, Giorgio A.
AU - Polito, Andrea
AU - Belliato, Mirko
AU - Pasero, Daniela
AU - Beduneau, Gaetan
AU - Wysocki, Marc
AU - Brunner, Josef X.
AU - Braschi, Antonio
AU - Brochard, Laurent
AU - Mancebo, Jordi
AU - Ranieri, V. Marco
AU - Richard, Jean Christophe M
AU - Arthur, S. Slutsky
PY - 2010/8
Y1 - 2010/8
N2 - Objective: To compare the short-term effects of adaptive support ventilation (ASV), an advanced closed-loop mode, with conventional volume or pressurecontrol ventilation in patients passively ventilated for acute respiratory failure. Design: Prospective crossover interventional multicenter trial. Setting: Six European academic intensive care units. Patients: Eighty-eight patients in three groups: patients with no obvious lung disease (n = 22), restrictive lung disease (n = 36) or obstructive lung disease (n = 30). Interventions: After measurements on conventional ventilation (CV) as set by the patients' clinicians, each patient was switched to ASV set to obtain the same minute ventilation as during CV (isoMV condition). If this resulted in a change in PaCO2, the minute ventilation setting of ASV was readjusted to achieve the same PaCO2 as in CV (isoCO2 condition). Measurements and results: Compared with CV, PaCO2 during ASV in isoMV condition and minute ventilation during ASV in isoCO2 condition were slightly lower, with lower inspiratory work/minute performed by the ventilator (p
AB - Objective: To compare the short-term effects of adaptive support ventilation (ASV), an advanced closed-loop mode, with conventional volume or pressurecontrol ventilation in patients passively ventilated for acute respiratory failure. Design: Prospective crossover interventional multicenter trial. Setting: Six European academic intensive care units. Patients: Eighty-eight patients in three groups: patients with no obvious lung disease (n = 22), restrictive lung disease (n = 36) or obstructive lung disease (n = 30). Interventions: After measurements on conventional ventilation (CV) as set by the patients' clinicians, each patient was switched to ASV set to obtain the same minute ventilation as during CV (isoMV condition). If this resulted in a change in PaCO2, the minute ventilation setting of ASV was readjusted to achieve the same PaCO2 as in CV (isoCO2 condition). Measurements and results: Compared with CV, PaCO2 during ASV in isoMV condition and minute ventilation during ASV in isoCO2 condition were slightly lower, with lower inspiratory work/minute performed by the ventilator (p
KW - Breathing pattern
KW - Carbon dioxide elimination
KW - Closed-loop ventilation
KW - Mechanical ventilation
KW - Respiratory mechanics
KW - Work of breathing
UR - http://www.scopus.com/inward/record.url?scp=77956173527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956173527&partnerID=8YFLogxK
U2 - 10.1007/s00134-010-1917-2
DO - 10.1007/s00134-010-1917-2
M3 - Article
C2 - 20502870
AN - SCOPUS:77956173527
SN - 0342-4642
VL - 36
SP - 1371
EP - 1379
JO - Intensive Care Medicine
JF - Intensive Care Medicine
IS - 8
ER -