Acute myelitis as presenting symptom of HIV-HTLV-1 co-infection

Alberto Cucca; L. Stragapede; Lucia Antonutti; Mauro Catalan; Ilaria Caracciolo; Romina Valentinotti; A. Granato; Pierlanfranco D'Agaro

doi:10.1007/s13365-016-0455-2

Acute myelitis as presenting symptom of HIV-HTLV-1 co-infection

Alberto Cucca, L. Stragapede, Lucia Antonutti, Mauro Catalan, Ilaria Caracciolo, Romina Valentinotti, A. Granato, Pierlanfranco D'Agaro

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

A 21-year-old woman presented with acute-onset spastic paraparesis. The MRI spinal scan revealed a contrast-enhanced T2 hyperintensity between C5–T2. The most common neurotropic pathogens were excluded by first level tests. Under suspicion of an acute immune-mediated myelitis, a corticosteroid therapy was administered. However, a seropositivity for both human immunodeficiency virus (HIV) type 1 and human T-lymphotropic virus (HTLV) subsequently emerged. An antiretroviral therapy was started while steroids discontinued. Patient’s clinical conditions remained unchanged. HIV-HTLV-1 co-infection should be included in the differential diagnosis of any acute myelitis, even in patients with a preserved immune status and no risk factors.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Journal of NeuroVirology
DOIs	https://doi.org/10.1007/s13365-016-0455-2
Publication status	Accepted/In press - May 31 2016

Keywords

HIV
HTLV
Myelitis

ASJC Scopus subject areas

Virology
Clinical Neurology
Cellular and Molecular Neuroscience
Neurology

Access to Document

10.1007/s13365-016-0455-2

Cite this

@article{165c9f59dd1c408c974711273b12fbf8,

title = "Acute myelitis as presenting symptom of HIV-HTLV-1 co-infection",

abstract = "A 21-year-old woman presented with acute-onset spastic paraparesis. The MRI spinal scan revealed a contrast-enhanced T2 hyperintensity between C5–T2. The most common neurotropic pathogens were excluded by first level tests. Under suspicion of an acute immune-mediated myelitis, a corticosteroid therapy was administered. However, a seropositivity for both human immunodeficiency virus (HIV) type 1 and human T-lymphotropic virus (HTLV) subsequently emerged. An antiretroviral therapy was started while steroids discontinued. Patient{\textquoteright}s clinical conditions remained unchanged. HIV-HTLV-1 co-infection should be included in the differential diagnosis of any acute myelitis, even in patients with a preserved immune status and no risk factors.",

keywords = "HIV, HTLV, Myelitis",

author = "Alberto Cucca and L. Stragapede and Lucia Antonutti and Mauro Catalan and Ilaria Caracciolo and Romina Valentinotti and A. Granato and Pierlanfranco D'Agaro",

year = "2016",

month = may,

day = "31",

doi = "10.1007/s13365-016-0455-2",

language = "English",

pages = "1--5",

journal = "Journal of NeuroVirology",

issn = "1355-0284",

publisher = "Springer New York",

}

TY - JOUR

T1 - Acute myelitis as presenting symptom of HIV-HTLV-1 co-infection

AU - Cucca, Alberto

AU - Stragapede, L.

AU - Antonutti, Lucia

AU - Catalan, Mauro

AU - Caracciolo, Ilaria

AU - Valentinotti, Romina

AU - Granato, A.

AU - D'Agaro, Pierlanfranco

PY - 2016/5/31

Y1 - 2016/5/31

N2 - A 21-year-old woman presented with acute-onset spastic paraparesis. The MRI spinal scan revealed a contrast-enhanced T2 hyperintensity between C5–T2. The most common neurotropic pathogens were excluded by first level tests. Under suspicion of an acute immune-mediated myelitis, a corticosteroid therapy was administered. However, a seropositivity for both human immunodeficiency virus (HIV) type 1 and human T-lymphotropic virus (HTLV) subsequently emerged. An antiretroviral therapy was started while steroids discontinued. Patient’s clinical conditions remained unchanged. HIV-HTLV-1 co-infection should be included in the differential diagnosis of any acute myelitis, even in patients with a preserved immune status and no risk factors.

AB - A 21-year-old woman presented with acute-onset spastic paraparesis. The MRI spinal scan revealed a contrast-enhanced T2 hyperintensity between C5–T2. The most common neurotropic pathogens were excluded by first level tests. Under suspicion of an acute immune-mediated myelitis, a corticosteroid therapy was administered. However, a seropositivity for both human immunodeficiency virus (HIV) type 1 and human T-lymphotropic virus (HTLV) subsequently emerged. An antiretroviral therapy was started while steroids discontinued. Patient’s clinical conditions remained unchanged. HIV-HTLV-1 co-infection should be included in the differential diagnosis of any acute myelitis, even in patients with a preserved immune status and no risk factors.

KW - HIV

KW - HTLV

KW - Myelitis

UR - http://www.scopus.com/inward/record.url?scp=84973163963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973163963&partnerID=8YFLogxK

U2 - 10.1007/s13365-016-0455-2

DO - 10.1007/s13365-016-0455-2

M3 - Article

SN - 1355-0284

SP - 1

EP - 5

JO - Journal of NeuroVirology

JF - Journal of NeuroVirology

ER -

Acute myelitis as presenting symptom of HIV-HTLV-1 co-infection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this