Acute hepatitis b in children with papular acrodermatitis

Massimo Colombo, Maria Grazia Rumi, Evangelista Sagnelli, Ferdinando Gianotti, Fiorenzo Paronetto

Research output: Contribution to journalArticlepeer-review


Thirteen children who had repeated liver biopsies over a period of 2-16 years after the onset of papular acrodermatitis (PAC) were studied retrospectively. Six patients, rebiopsied within 36 months after the onset of PAC, had histologic evidence of chronic periportal hepatitis. However, repeated biopsies in 3 of the patients revealed a normal liver or chronic portal hepatitis. Whereas all patients had at the end of the observation markers of hepatitis B virus infection, 8 of the 10 patients studied had HBs antigenemia. These data indicate that severe active liver disease may regress without treatment in patients who have had PAC. However, the high frequency of a chronic HBsAg-carrier state among these patients suggests either an inefficient clearance of the virus or an altered immune reaction..

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalFetal and Pediatric Pathology
Issue number2-3
Publication statusPublished - 1986


  • Chronic hepatitis
  • Hepatitis B infection
  • Liver biopsy
  • Papular acrodermatitis of childhood

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health


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