Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex

C. Piersimoni; E. Tortoli; M. T. Mascellino; C. Passerini Tosi; G. Sbaraglia; F. Mandler; F. Bistoni; S. Bornigia; G. De Sio; A. Goglio; E. Iona; M. B. Pasticci; M. T. Simonetti

doi:10.1093/jac/36.3.497

Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex

C. Piersimoni, E. Tortoli, M. T. Mascellino, C. Passerini Tosi, G. Sbaraglia, F. Mandler, F. Bistoni, S. Bornigia, G. De Sio, A. Goglio, E. Iona, M. B. Pasticci, M. T. Simonetti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The activity of seven antimicrobial agents (and five two-drug combinations and five three-drug combinations) was investigated against 37 clinical isolates of Mycobacterium avium recovered from blood cultures of AIDS patients. The susceptibility tests were performed in Middlebrook 7H12 broth using a radiometric method. MICs of amikacin, ciprofloxacin, clarithromycin, clofazimine, ethambutol, rifabutin and sparfloxacin were determined. Five antimicrobial agents were tested in combination with clarithromycin and also with clarithromycin plus amikacin to look for possible synergic activity. Synergic activity in combination with clarithromycin and with clarithromycin plus amikacin, was detected for rifabutin (54% and 51% of isolates, respectively), clofazimine (38% and 35%), ethambutol (16% and 32%), ciprofloxacin (8% and 14%) and sparfloxacin (3% and 8%). No antagonism was observed. We conclude that clarithromycin is an essential component in the chemotherapy of M. avium complex disease.

Original language	English
Pages (from-to)	497-502
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	36
Issue number	3
DOIs	https://doi.org/10.1093/jac/36.3.497
Publication status	Published - Sept 1995

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Physiology (medical)
Infectious Diseases
Pharmacology (medical)
Pharmacology
Microbiology

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Piersimoni, C., Tortoli, E., Mascellino, M. T., Tosi, C. P., Sbaraglia, G., Mandler, F., Bistoni, F., Bornigia, S., Sio, G. D., Goglio, A., Iona, E., Pasticci, M. B., & Simonetti, M. T. (1995). Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex. Journal of Antimicrobial Chemotherapy, 36(3), 497-502. https://doi.org/10.1093/jac/36.3.497

Piersimoni, C, Tortoli, E, Mascellino, MT, Tosi, CP, Sbaraglia, G, Mandler, F, Bistoni, F, Bornigia, S, Sio, GD, Goglio, A, Iona, E, Pasticci, MB & Simonetti, MT 1995, 'Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex', Journal of Antimicrobial Chemotherapy, vol. 36, no. 3, pp. 497-502. https://doi.org/10.1093/jac/36.3.497

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abstract = "The activity of seven antimicrobial agents (and five two-drug combinations and five three-drug combinations) was investigated against 37 clinical isolates of Mycobacterium avium recovered from blood cultures of AIDS patients. The susceptibility tests were performed in Middlebrook 7H12 broth using a radiometric method. MICs of amikacin, ciprofloxacin, clarithromycin, clofazimine, ethambutol, rifabutin and sparfloxacin were determined. Five antimicrobial agents were tested in combination with clarithromycin and also with clarithromycin plus amikacin to look for possible synergic activity. Synergic activity in combination with clarithromycin and with clarithromycin plus amikacin, was detected for rifabutin (54% and 51% of isolates, respectively), clofazimine (38% and 35%), ethambutol (16% and 32%), ciprofloxacin (8% and 14%) and sparfloxacin (3% and 8%). No antagonism was observed. We conclude that clarithromycin is an essential component in the chemotherapy of M. avium complex disease.",

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Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex

Abstract

ASJC Scopus subject areas

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