Activation of dopamine D1-like receptors excites LTS interneurons of the striatum

Diego Centonze, Enrico Bracci, Antonio Pisani, Paolo Gubellini, Giorgio Bernardi, Paolo Calabresi

Research output: Contribution to journalArticlepeer-review


Dopamine (DA) has a crucial role in the modulation of striatal neuron activity. Along with projection cells, striatal interneurons receive dense dopaminergic innervation from midbrain neurons, thus, also suggesting that these intrinsic cells represent a synaptic target for DA action in the striatum. In the present study, we investigated the effects of DA on low-threshold spike (LTS) interneurons of the rat striatum, by means of in vitro whole-cell patch-clamp electrophysiological recordings. Dopamine depolarized LTS cells, a pharmacological effect prevented by D1- but not D2-like DA receptor antagonists. The membrane depolarization produced by DA was sufficient to trigger action potential discharge in the recorded cells and was insensitive to tetrodotoxin and glutamate receptor antagonists. In addition, this pharmacological effect was mimicked by D1- but not D2-like DA receptor agonists, implying the selective involvement of D1-like receptors in this action.

Original languageEnglish
Pages (from-to)2049-2052
Number of pages4
JournalEuropean Journal of Neuroscience
Issue number12
Publication statusPublished - 2002


  • Electrophysiology
  • GABA
  • Inhibitory transmission
  • Nitric oxide

ASJC Scopus subject areas

  • Neuroscience(all)


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