Action of ethanol and salsolinol on opiate receptor function

L. Lucchi; A. Bosio; P. F. Spano; M. Trabucchi

doi:10.1016/0006-8993(82)90297-9

Action of ethanol and salsolinol on opiate receptor function

L. Lucchi, A. Bosio, P. F. Spano, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Ethanol may act at the enkephalinergic receptor level through condensation products such as salsolinol. This fact has been demonstrated by studying the 'in vitro' salsolinol interaction on enkephalinergic receptor sites labeled by [³H-Met]enkephalin. The modification induced by chronic ethanol and salsolinol on this neuronal system is a reduction of the affinity of the receptor for its ligand. These data suggest that a down regulation process due to the continuous opiate receptor stimulation occurs after ethanol administration.

Original language	English
Pages (from-to)	506-510
Number of pages	5
Journal	Brain Research
Volume	232
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(82)90297-9
Publication status	Published - Jan 28 1982

Keywords

ethanol
opiate receptors
salsolinol

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(82)90297-9

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AU - Bosio, A.

AU - Spano, P. F.

AU - Trabucchi, M.

PY - 1982/1/28

Y1 - 1982/1/28

N2 - Ethanol may act at the enkephalinergic receptor level through condensation products such as salsolinol. This fact has been demonstrated by studying the 'in vitro' salsolinol interaction on enkephalinergic receptor sites labeled by [3H-Met]enkephalin. The modification induced by chronic ethanol and salsolinol on this neuronal system is a reduction of the affinity of the receptor for its ligand. These data suggest that a down regulation process due to the continuous opiate receptor stimulation occurs after ethanol administration.

AB - Ethanol may act at the enkephalinergic receptor level through condensation products such as salsolinol. This fact has been demonstrated by studying the 'in vitro' salsolinol interaction on enkephalinergic receptor sites labeled by [3H-Met]enkephalin. The modification induced by chronic ethanol and salsolinol on this neuronal system is a reduction of the affinity of the receptor for its ligand. These data suggest that a down regulation process due to the continuous opiate receptor stimulation occurs after ethanol administration.

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KW - opiate receptors

KW - salsolinol

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Action of ethanol and salsolinol on opiate receptor function

Abstract

Keywords

ASJC Scopus subject areas

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