Acromegaly is associated with increased cancer risk: a survey in Italy

M Terzolo; G Reimondo; P Berchialla; E Ferrante; E Malchiodi; L De Marinis; R Pivonello; S Grottoli; M Losa; S Cannavo; D Ferone; M Montini; M Bondanelli; E De Menis; C Martini; E Puxeddu; A Velardo; A Peri; M Faustini-Fustini; P Tita; F Pigliaru; G Peraga; G Borretta; C Scaroni; N Bazzoni; A Bianchi; A Berton; AL Serban; R Baldelli; LM Fatti; A Colao; M Arosio; for the Italian Study Group of Acromegaly

doi:10.1530/ERC-16-0553

Acromegaly is associated with increased cancer risk: a survey in Italy

M Terzolo, G Reimondo, P Berchialla, E Ferrante, E Malchiodi, L De Marinis, R Pivonello, S Grottoli, M Losa, S Cannavo, D Ferone, M Montini, M Bondanelli, E De Menis, C Martini, E Puxeddu, A Velardo, A Peri, M Faustini-Fustini, P TitaF Pigliaru, G Peraga, G Borretta, C Scaroni, N Bazzoni, A Bianchi, A Berton, AL Serban, R Baldelli, LM Fatti, A Colao, M Arosio, for the Italian Study Group of Acromegaly

Research output: Contribution to journal › Article › peer-review

Abstract

It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18-1.68, P

Original language	English
Pages (from-to)	495-504
Number of pages	10
Journal	Endocrine-Related Cancer
Volume	24
Issue number	9
DOIs	https://doi.org/10.1530/ERC-16-0553
Publication status	Published - 2017

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Terzolo, M., Reimondo, G., Berchialla, P., Ferrante, E., Malchiodi, E., De Marinis, L., Pivonello, R., Grottoli, S., Losa, M., Cannavo, S., Ferone, D., Montini, M., Bondanelli, M., De Menis, E., Martini, C., Puxeddu, E., Velardo, A., Peri, A., Faustini-Fustini, M., ... Acromegaly, F. T. I. S. G. O. (2017). Acromegaly is associated with increased cancer risk: a survey in Italy. Endocrine-Related Cancer, 24(9), 495-504. https://doi.org/10.1530/ERC-16-0553

Terzolo, M, Reimondo, G, Berchialla, P, Ferrante, E, Malchiodi, E, De Marinis, L, Pivonello, R, Grottoli, S, Losa, M, Cannavo, S, Ferone, D, Montini, M, Bondanelli, M, De Menis, E, Martini, C, Puxeddu, E, Velardo, A, Peri, A , Faustini-Fustini, M, Tita, P, Pigliaru, F, Peraga, G, Borretta, G, Scaroni, C, Bazzoni, N, Bianchi, A, Berton, A, Serban, AL, Baldelli, R, Fatti, LM, Colao, A, Arosio, M & Acromegaly, FTISGO 2017, 'Acromegaly is associated with increased cancer risk: a survey in Italy', Endocrine-Related Cancer, vol. 24, no. 9, pp. 495-504. https://doi.org/10.1530/ERC-16-0553

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title = "Acromegaly is associated with increased cancer risk: a survey in Italy",

abstract = "It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18-1.68, P ",

author = "M Terzolo and G Reimondo and P Berchialla and E Ferrante and E Malchiodi and {De Marinis}, L and R Pivonello and S Grottoli and M Losa and S Cannavo and D Ferone and M Montini and M Bondanelli and {De Menis}, E and C Martini and E Puxeddu and A Velardo and A Peri and M Faustini-Fustini and P Tita and F Pigliaru and G Peraga and G Borretta and C Scaroni and N Bazzoni and A Bianchi and A Berton and AL Serban and R Baldelli and LM Fatti and A Colao and M Arosio and Acromegaly, {for the Italian Study Group of}",

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AU - Terzolo, M

AU - Reimondo, G

AU - Berchialla, P

AU - Ferrante, E

AU - Malchiodi, E

AU - De Marinis, L

AU - Pivonello, R

AU - Grottoli, S

AU - Losa, M

AU - Cannavo, S

AU - Ferone, D

AU - Montini, M

AU - Bondanelli, M

AU - De Menis, E

AU - Martini, C

AU - Puxeddu, E

AU - Velardo, A

AU - Peri, A

AU - Faustini-Fustini, M

AU - Tita, P

AU - Pigliaru, F

AU - Peraga, G

AU - Borretta, G

AU - Scaroni, C

AU - Bazzoni, N

AU - Bianchi, A

AU - Berton, A

AU - Serban, AL

AU - Baldelli, R

AU - Fatti, LM

AU - Colao, A

AU - Arosio, M

AU - Acromegaly, for the Italian Study Group of

PY - 2017

Y1 - 2017

N2 - It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18-1.68, P

AB - It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18-1.68, P

U2 - 10.1530/ERC-16-0553

DO - 10.1530/ERC-16-0553

M3 - Article

SN - 1351-0088

VL - 24

SP - 495

EP - 504

JO - Endocrine-Related Cancer

JF - Endocrine-Related Cancer

IS - 9

ER -

Acromegaly is associated with increased cancer risk: a survey in Italy

Abstract

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