Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function

C. L. Balduini, C. C. Stella, V. Rosti, G. Bertolino, P. Noris, E. Ascari

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A periodic fall of platelet number characterizes an acquired pathological condition named cyclic thrombocytopenia. We observed a patient in whom the episodes of thrombocytopenia (platelet number less than 50 x 109/l) were followed regularly by thrombocytosis (700-2300 x 109 platelets/l). The period of platelet count fluctuation was about 40 d. Morphological examination of bone marrow showed the cyclic disappearance of mature and immature megakaryocytes; bone marrow cultures revealed a periodic severe defect of both multilineage and single-lineage progenitor cell growth. When platelet count was falling, a mild defect of platelet aggregation and ATP release was observed, while platelet function was normal when platelet count was rising. Prednisone, thymopentine, high-dose intravenous γ-globulin and splenectomy were without effect. After 4 years of cyclic platelet and megakaryocyte fluctuations, stable amegakaryocytic thrombocypenia developed and the patient died of haemorrhagic stroke.

Original languageEnglish
Pages (from-to)718-722
Number of pages5
JournalBritish Journal of Haematology
Issue number4
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Hematology


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