TY - JOUR
T1 - Acetylcysteine and contrast agent-associated nephrotoxicity
AU - Briguori, Carlo
AU - Manganelli, Fiore
AU - Scarpato, Pierfranco
AU - Elia, Pietro Paolo
AU - Golia, Bruno
AU - Riviezzo, Guido
AU - Lepore, Stefano
AU - Librera, Mariateresa
AU - Villari, Bruno
AU - Colombo, Antonio
AU - Ricciardelli, Bruno
PY - 2002/7/17
Y1 - 2002/7/17
N2 - OBJECTIVES: Prophylactic acetylcysteine along with hydration seems to be better than hydration alone in preventing the reduction in renal function induced by a contrast dye. BACKGROUND: Contrast media can lead to acute renal failure that may occasionally require hemodialysis. METHODS: One hundred eighty-three consecutive patients with impairment of renal function, undergoing coronary and/or peripheral angiography and/or angioplasty, were randomly assigned to receive 0.45% saline intravenously and acetylcysteine (600 mg orally twice daily; group A, n = 92) or 0.45% saline intravenously alone (group B, n = 91) before and after nonionic, low-osmolality contrast dye administration. RESULTS: The baseline serum creatinine concentrations were similar (1.5 ± 0.4 mg/dl in group A vs. 1.5 ± 0.4 mg/dl in group B; p = 0.37). An increase of ≥25% in the baseline creatinine level 48 h after the procedure occurred in 6 (6.5%) of 92 patients in group A and in 10 (11%) of 91 patients in group B (p = 0.22). In the subgroup with a low (
AB - OBJECTIVES: Prophylactic acetylcysteine along with hydration seems to be better than hydration alone in preventing the reduction in renal function induced by a contrast dye. BACKGROUND: Contrast media can lead to acute renal failure that may occasionally require hemodialysis. METHODS: One hundred eighty-three consecutive patients with impairment of renal function, undergoing coronary and/or peripheral angiography and/or angioplasty, were randomly assigned to receive 0.45% saline intravenously and acetylcysteine (600 mg orally twice daily; group A, n = 92) or 0.45% saline intravenously alone (group B, n = 91) before and after nonionic, low-osmolality contrast dye administration. RESULTS: The baseline serum creatinine concentrations were similar (1.5 ± 0.4 mg/dl in group A vs. 1.5 ± 0.4 mg/dl in group B; p = 0.37). An increase of ≥25% in the baseline creatinine level 48 h after the procedure occurred in 6 (6.5%) of 92 patients in group A and in 10 (11%) of 91 patients in group B (p = 0.22). In the subgroup with a low (
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U2 - 10.1016/S0735-1097(02)01958-7
DO - 10.1016/S0735-1097(02)01958-7
M3 - Article
C2 - 12106935
AN - SCOPUS:0037125366
SN - 0735-1097
VL - 40
SP - 298
EP - 303
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 2
ER -