Accumulation of 99m Tc-Sn-pyrophosphate in pleural effusions

Carlo Aprile, Giovanni Bernardo, Mauro Carena, Angelo Favino, Gioacchino Robustelli Della Cuna, Maria Rosa Strada, Spartaco Mascherpa

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Accumulation of 99m Tc-Sn-pyrophosphate in pleural effusions has been evaluated in 56 patients grouped as follows: 8 with bacterial effusion (Group A), 27 with malignant effusion treated by local and/or parenteral antitumor chemotherapy (Group B), 21 with malignant effusion treated only by supportive therapy (Group C). Results, expressed as effusion to plasma PPi ratio, ranged from 0.1 to 0.28 in group A, from 0.04 to 0.64 in group B and from 0.60 to 1.73 in group C, with significant differences among the three groups. In no case was uptake found in cells of the sediment. Chemical analysis (including total and ionized calcium, total protein, acid and alkaline phosphatase) of plasma and exudate in neoplastic patients showed a slight, but significant, difference between groups B and C as regards plasma-effusion gradient for total calcium and acid phosphatase. Negative correlation also exists between effusion to plasma PPi ratio and plasma-exudate gradient for ionized calcium in neoplastic patients. The data support the hypothesis that acid phosphatase content and calcium gradient are among the factors involved in the mechanism of PPi accumulation in pleural effusions.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalEuropean Journal Of Nuclear Medicine
Issue number4
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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