Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Claudio Babiloni; Claudio Del Percio; Maria Teresa Pascarelli; Roberta Lizio; Giuseppe Noce; Susanna Lopez; Marco Rizzo; Raffaele Ferri; Andrea Soricelli; Flavio Nobili; Dario Arnaldi; Francesco Famà; Francesco Orzi; Carla Buttinelli; Franco Giubilei; Marco Salvetti; Virginia Cipollini; Raffaella Franciotti; Marco Onofrj; Paola Stirpe; Peter Fuhr; Ute Gschwandtner; Gerhard Ransmayr; Dag Aarsland; Lucilla Parnetti; Lucia Farotti; Moira Marizzoni; Fabrizia D'Antonio; Carlo De Lena; Bahar Güntekin; Lutfu Hanoğlu; Görsev Yener; Derya Durusu Emek-Savaş; Antonio Ivano Triggiani; John Paul Taylor; Ian McKeith; Fabrizio Stocchi; Laura Vacca; Harald Hampel; Giovanni B Frisoni; Maria Francesca De Pandis; Laura Bonanni

doi:10.1016/j.neurobiolaging.2019.01.013

Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Claudio Babiloni, Claudio Del Percio, Maria Teresa Pascarelli, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Marco Rizzo, Raffaele Ferri, Andrea Soricelli, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Salvetti, Virginia Cipollini, Raffaella Franciotti, Marco Onofrj, Paola StirpePeter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Dag Aarsland, Lucilla Parnetti, Lucia Farotti, Moira Marizzoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Harald Hampel, Giovanni B Frisoni, Maria Francesca De Pandis, Laura Bonanni

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Research output: Contribution to journal › Article › peer-review

Abstract

Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.

Original language	English
Pages (from-to)	112-127
Number of pages	16
Journal	Neurobiology of Aging
Volume	77
DOIs	https://doi.org/10.1016/j.neurobiolaging.2019.01.013
Publication status	Published - May 2019

Keywords

Aged
Alpha Rhythm
Alzheimer Disease/complications
Cerebral Cortex/physiopathology
Cognitive Dysfunction/etiology
Female
Humans
Lewy Body Disease/complications
Male
Rest/physiology

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Babiloni, C., Del Percio, C., Pascarelli, M. T., Lizio, R., Noce, G., Lopez, S., Rizzo, M., Ferri, R., Soricelli, A., Nobili, F., Arnaldi, D., Famà, F., Orzi, F., Buttinelli, C., Giubilei, F., Salvetti, M., Cipollini, V., Franciotti, R., Onofrj, M., ... Bonanni, L. (2019). Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases. Neurobiology of Aging, 77, 112-127. https://doi.org/10.1016/j.neurobiolaging.2019.01.013

Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases. / Babiloni, Claudio; Del Percio, Claudio; Pascarelli, Maria Teresa et al.

In: Neurobiology of Aging, Vol. 77, 05.2019, p. 112-127.

Research output: Contribution to journal › Article › peer-review

Babiloni, C, Del Percio, C, Pascarelli, MT, Lizio, R, Noce, G, Lopez, S, Rizzo, M, Ferri, R, Soricelli, A, Nobili, F, Arnaldi, D, Famà, F, Orzi, F, Buttinelli, C, Giubilei, F, Salvetti, M, Cipollini, V, Franciotti, R, Onofrj, M, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Aarsland, D, Parnetti, L, Farotti, L, Marizzoni, M, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Yener, G, Emek-Savaş, DD, Triggiani, AI, Taylor, JP, McKeith, I, Stocchi, F, Vacca, L, Hampel, H, Frisoni, GB, De Pandis, MF & Bonanni, L 2019, 'Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases', Neurobiology of Aging, vol. 77, pp. 112-127. https://doi.org/10.1016/j.neurobiolaging.2019.01.013

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title = "Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases",

abstract = "Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.",

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author = "Claudio Babiloni and {Del Percio}, Claudio and Pascarelli, {Maria Teresa} and Roberta Lizio and Giuseppe Noce and Susanna Lopez and Marco Rizzo and Raffaele Ferri and Andrea Soricelli and Flavio Nobili and Dario Arnaldi and Francesco Fam{\`a} and Francesco Orzi and Carla Buttinelli and Franco Giubilei and Marco Salvetti and Virginia Cipollini and Raffaella Franciotti and Marco Onofrj and Paola Stirpe and Peter Fuhr and Ute Gschwandtner and Gerhard Ransmayr and Dag Aarsland and Lucilla Parnetti and Lucia Farotti and Moira Marizzoni and Fabrizia D'Antonio and {De Lena}, Carlo and Bahar G{\"u}ntekin and Lutfu Hanoğlu and G{\"o}rsev Yener and Emek-Sava{\c s}, {Derya Durusu} and Triggiani, {Antonio Ivano} and Taylor, {John Paul} and Ian McKeith and Fabrizio Stocchi and Laura Vacca and Harald Hampel and Frisoni, {Giovanni B} and {De Pandis}, {Maria Francesca} and Laura Bonanni",

year = "2019",

month = may,

doi = "10.1016/j.neurobiolaging.2019.01.013",

language = "English",

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pages = "112--127",

journal = "Neurobiology of Aging",

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T1 - Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

AU - Babiloni, Claudio

AU - Del Percio, Claudio

AU - Pascarelli, Maria Teresa

AU - Lizio, Roberta

AU - Noce, Giuseppe

AU - Lopez, Susanna

AU - Rizzo, Marco

AU - Ferri, Raffaele

AU - Soricelli, Andrea

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Orzi, Francesco

AU - Buttinelli, Carla

AU - Giubilei, Franco

AU - Salvetti, Marco

AU - Cipollini, Virginia

AU - Franciotti, Raffaella

AU - Onofrj, Marco

AU - Stirpe, Paola

AU - Fuhr, Peter

AU - Gschwandtner, Ute

AU - Ransmayr, Gerhard

AU - Aarsland, Dag

AU - Parnetti, Lucilla

AU - Farotti, Lucia

AU - Marizzoni, Moira

AU - D'Antonio, Fabrizia

AU - De Lena, Carlo

AU - Güntekin, Bahar

AU - Hanoğlu, Lutfu

AU - Yener, Görsev

AU - Emek-Savaş, Derya Durusu

AU - Triggiani, Antonio Ivano

AU - Taylor, John Paul

AU - McKeith, Ian

AU - Stocchi, Fabrizio

AU - Vacca, Laura

AU - Hampel, Harald

AU - Frisoni, Giovanni B

AU - De Pandis, Maria Francesca

AU - Bonanni, Laura

PY - 2019/5

Y1 - 2019/5

N2 - Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.

AB - Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.

KW - Aged

KW - Alpha Rhythm

KW - Alzheimer Disease/complications

KW - Cerebral Cortex/physiopathology

KW - Cognitive Dysfunction/etiology

KW - Female

KW - Humans

KW - Lewy Body Disease/complications

KW - Male

KW - Rest/physiology

U2 - 10.1016/j.neurobiolaging.2019.01.013

DO - 10.1016/j.neurobiolaging.2019.01.013

M3 - Article

C2 - 30797169

SN - 0197-4580

VL - 77

SP - 112

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JO - Neurobiology of Aging

JF - Neurobiology of Aging

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