Abnormalities in arachidonic acid metabolites in nephrotoxic glomerular injury

Research output: Contribution to journalArticlepeer-review


Arachidonic acid metabolites are suspected of contributing in various ways to major pathophysiological events that occur in toxic and immune glomerular injury. This paper focuses on the role of arachidonate metabolites in the experimental models of adriamycin nephrosis and cyclosporin A nephrotoxicity in rats as examples, respectively, of a toxic nephropathy characterized by increasedglomerular permeability to proteins and a toxic nephropathy with macrophage accumulation and progressively deteriorating renal function. The important pathogenic contribution of thromboxane A2 to the impairment of renal function in these experimental models is discussed.

Original languageEnglish
Pages (from-to)65-75
Number of pages11
JournalToxicology Letters
Issue number1-3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Toxicology


Dive into the research topics of 'Abnormalities in arachidonic acid metabolites in nephrotoxic glomerular injury'. Together they form a unique fingerprint.

Cite this