Abnormal functional lateralization of the sensorimotor cortex in patients with schizophrenia

Venkata S. Mattay, Joseph H. Callicott, Alessandro Bertolino, Attanagoda K S Santha, Kathleen A. Tallent, Terry E. Goldberg, Joseph A. Frank, Daniel R. Weinberger

Research output: Contribution to journalArticlepeer-review


PREVIOUS neuroimaging studies have suggested that patients with schizophrenia fail to recruit appropriate local patterns of cortical responses to cognitive tasks. We investigated whether patients with schizophrenia show a normal focal response to a simple motor task. Seven strongly right-handed patients with schizophrenia and seven strongly right- handed normal subjects performed motor tasks of increasing complexity. Patients were unable to recruit as focal a response even to a simple, automatic sequential finger movement task. They showed greater ipsilateral activation in the primary sensorimotor and lateral premotor regions and had a significantly lower laterality quotient than normal subjects. These phenomena increased with the complexity of the task. These results demonstrate a functional disturbance in the cortical motor circuitry of patients with schizophrenia.

Original languageEnglish
Pages (from-to)2977-2984
Number of pages8
Issue number13
Publication statusPublished - 1997


  • Cortex
  • fMRI
  • Functional imaging
  • Lateralization
  • Motor function
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)


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