TY - JOUR
T1 - Aberrant DNA methylation impacts gene expression and prognosis in breast cancer subtypes
AU - Györffy, Balázs
AU - Bottai, Giulia
AU - Fleischer, Thomas
AU - Munkácsy, Gyöngyi
AU - Budczies, Jan
AU - Paladini, Laura
AU - Børresen-Dale, Anne Lise
AU - Kristensen, Vessela N.
AU - Santarpia, Libero
PY - 2016/1/1
Y1 - 2016/1/1
N2 - DNA methylation has a substantial impact on gene expression, affecting the prognosis of breast cancer (BC) patients dependent on molecular subtypes. In this study, we investigated the prognostic relevance of the expression of genes reported as aberrantly methylated, and the link between gene expression and DNA methylation in BC subtypes. The prognostic value of the expression of 144 aberrantly methylated genes was evaluated in ER+/HER2-, HER2+, and ER-/HER2- molecular BC subtypes, in a meta-analysis of two large transcriptomic cohorts of BC patients (n=1,938 and n=1,640). The correlation between gene expression and DNA methylation in distinct gene regions was also investigated in an independent dataset of 104 BCs. Survival and Pearson correlation analyses were computed for each gene separately. The expression of 48 genes was significantly associated with BC prognosis (p
AB - DNA methylation has a substantial impact on gene expression, affecting the prognosis of breast cancer (BC) patients dependent on molecular subtypes. In this study, we investigated the prognostic relevance of the expression of genes reported as aberrantly methylated, and the link between gene expression and DNA methylation in BC subtypes. The prognostic value of the expression of 144 aberrantly methylated genes was evaluated in ER+/HER2-, HER2+, and ER-/HER2- molecular BC subtypes, in a meta-analysis of two large transcriptomic cohorts of BC patients (n=1,938 and n=1,640). The correlation between gene expression and DNA methylation in distinct gene regions was also investigated in an independent dataset of 104 BCs. Survival and Pearson correlation analyses were computed for each gene separately. The expression of 48 genes was significantly associated with BC prognosis (p
KW - breast cancer subtypes
KW - DNA methylation biomarkers
KW - gene expression
KW - immune genes
KW - prognosis
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U2 - 10.1002/ijc.29684
DO - 10.1002/ijc.29684
M3 - Article
C2 - 26174627
AN - SCOPUS:84944214300
SN - 0020-7136
VL - 138
SP - 87
EP - 97
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 1
ER -