A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort

Olivia Anna Skrobot; Amy Jayne McKnight; Peter Anthony Passmore; Davide Seripa; Patrizia Mecocci; Francesco Panza; Rajesh Kalaria; Gordon Wilcock; Marcus Munafò; Timo Erkinjuntti; Pekka Karhunen; Tanja Pessi; Mika Martiskainen; Seth Love; Patrick Gavin Kehoe

doi:10.3233/JAD-150862

A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort

Olivia Anna Skrobot, Amy Jayne McKnight, Peter Anthony Passmore, Davide Seripa, Patrizia Mecocci, Francesco Panza, Rajesh Kalaria, Gordon Wilcock, Marcus Munafò, Timo Erkinjuntti, Pekka Karhunen, Tanja Pessi, Mika Martiskainen, Seth Love, Patrick Gavin Kehoe

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Vascular cognitive impairment (VCI), including its severe form, vascular dementia (VaD), is the second most common form of dementia. The genetic etiology of sporadic VCI remains largely unknown. We previously conducted a systematic review and meta-analysis of all published genetic association studies of sporadic VCI prior to 6 July 2012, which demonstrated that APOE (ϵ4, ϵ2) and MTHFR (rs1801133) variants were associated with susceptibility for VCI. De novo genotyping was conducted in a new independent relatively large collaborative European cohort of VaD (n_max=549) and elderly non-demented samples (n_max=552). Where available, genotype data derived from Illumina's 610-quad array for 1210 GERAD1 control samples were also included in analyses of genes examined. Associations were tested using the Cochran-Armitage trend test: MTHFR rs1801133 (OR=1.36, 95 CI 1.16-1.58, p=

Original language	English
Pages (from-to)	981-989
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	53
Issue number	3
DOIs	https://doi.org/10.3233/JAD-150862
Publication status	Published - 2016

Keywords

Association
cognitive impairment
dementia
gene
meta-analysis
vascular

ASJC Scopus subject areas

Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-150862

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Skrobot, O. A., McKnight, A. J., Passmore, P. A., Seripa, D., Mecocci, P., Panza, F., Kalaria, R., Wilcock, G., Munafò, M., Erkinjuntti, T., Karhunen, P., Pessi, T., Martiskainen, M., Love, S., & Kehoe, P. G. (2016). A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort. Journal of Alzheimer's Disease, 53(3), 981-989. https://doi.org/10.3233/JAD-150862

Skrobot, OA, McKnight, AJ, Passmore, PA, Seripa, D, Mecocci, P, Panza, F, Kalaria, R, Wilcock, G, Munafò, M, Erkinjuntti, T, Karhunen, P, Pessi, T, Martiskainen, M, Love, S & Kehoe, PG 2016, 'A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort', Journal of Alzheimer's Disease, vol. 53, no. 3, pp. 981-989. https://doi.org/10.3233/JAD-150862

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A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort

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Keywords

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