A survey of reactive oxygen species and their role in dermatology

Mauro Maccarrone, Maria Valeria Catani, Stefano Iraci, Gerry Melino, Alessandro Finazzi Agrò

Research output: Contribution to journalArticlepeer-review


General description In this paper we present a survey of the main reactive oxygen species (ROS), their biological sources and the array of antioxidant enzymes and antiradical molecules which constitutes the cellular defense against ROS toxicity. We outline also the fundamentals of ROS biochemistry, in relation to the role of ROS in several human pathologies. Finally, we discuss with particular emphasis the involvement of ROS in dermatological diseases, highlighting the possible therapeutic application of antioxidants in skin care. Learning objective The reader will learn what ROS are, the identity of the anti-ROS defensive system in human cells and the manyfold roles of ROS in human physiopathology, and thus the potential application of antioxidants in clinical therapy.

Original languageEnglish
Pages (from-to)185-202
Number of pages18
JournalJournal of the European Academy of Dermatology and Venereology
Issue number3
Publication statusPublished - 1997


  • Antioxidant enzymes
  • Antiradical molecules
  • Dermatology
  • Reactive oxygen species

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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