A snapshot of exhaled nitric oxide and asthma characteristics: experience from high to low income countries

Patrizia Pignatti; Dina Visca; Stelios Loukides; Anne Grete Märtson; Jan Willem C. Alffenaar; Giovanni Battista Migliori; Antonio Spanevello

doi:10.1016/j.pulmoe.2020.10.016

A snapshot of exhaled nitric oxide and asthma characteristics: experience from high to low income countries

Patrizia Pignatti, Dina Visca, Stelios Loukides, Anne Grete Märtson, Jan Willem C. Alffenaar, Giovanni Battista Migliori, Antonio Spanevello

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Review article › peer-review

Abstract

Nitric oxide is a gas produced in the airways of asthmatic subjects and related to T2 inflammation. It can be measured as fractional nitric oxide (FeNO) in the exhaled air and used as a non-invasive, easy to evaluate, rapid marker. It is now widely used in many settings to determine airway inflammation. The aim of this narrative review is to report relationship between FeNO and the physiopathologic characteristics of asthmatic patients. Factors affecting FeNO levels have also been analysed as well as the impact of corticosteroid, target therapies and rehabilitation programs. Considering the availability of the test, spreading this methodology to low income countries has also been considered as a possibility for evaluating airway inflammation and monitoring adherence to inhaled corticosteroid therapy. PubMed data search has been performed restricted to English language papers. Research was limited to studies in adults unless studies in children were the only ones reported for a particular issue. This revision could be useful to summarize the role of FeNO in relation to asthma characteristics and help in the use of FeNO in different clinical settings particularly in low income countries.

Original language	English
Pages (from-to)	44-58
Number of pages	15
Journal	Pulmonology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.pulmoe.2020.10.016
Publication status	Published - Jan 1 2022

Keywords

Airway inflammation
Comorbidities
FeNO
Rehabilitation
Therapy

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.pulmoe.2020.10.016

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title = "A snapshot of exhaled nitric oxide and asthma characteristics: experience from high to low income countries",

abstract = "Nitric oxide is a gas produced in the airways of asthmatic subjects and related to T2 inflammation. It can be measured as fractional nitric oxide (FeNO) in the exhaled air and used as a non-invasive, easy to evaluate, rapid marker. It is now widely used in many settings to determine airway inflammation. The aim of this narrative review is to report relationship between FeNO and the physiopathologic characteristics of asthmatic patients. Factors affecting FeNO levels have also been analysed as well as the impact of corticosteroid, target therapies and rehabilitation programs. Considering the availability of the test, spreading this methodology to low income countries has also been considered as a possibility for evaluating airway inflammation and monitoring adherence to inhaled corticosteroid therapy. PubMed data search has been performed restricted to English language papers. Research was limited to studies in adults unless studies in children were the only ones reported for a particular issue. This revision could be useful to summarize the role of FeNO in relation to asthma characteristics and help in the use of FeNO in different clinical settings particularly in low income countries.",

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author = "Patrizia Pignatti and Dina Visca and Stelios Loukides and M{\"a}rtson, {Anne Grete} and Alffenaar, {Jan Willem C.} and Migliori, {Giovanni Battista} and Antonio Spanevello",

note = "Funding Information: AGM was funded by Marie Sk?odowska-Curie Actions [grant agreement no. 713660?PRONKJEWAIL?H2020-MSCA-COFUND-2015] outside the submitted work. Funding Information: AGM was funded by Marie Sk{\l}odowska-Curie Actions [grant agreement no. 713660—PRONKJEWAIL—H2020-MSCA-COFUND-2015 ] outside the submitted work. Publisher Copyright: {\textcopyright} 2020 Sociedade Portuguesa de Pneumologia",

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AU - Alffenaar, Jan Willem C.

AU - Migliori, Giovanni Battista

AU - Spanevello, Antonio

N1 - Funding Information: AGM was funded by Marie Sk?odowska-Curie Actions [grant agreement no. 713660?PRONKJEWAIL?H2020-MSCA-COFUND-2015] outside the submitted work. Funding Information: AGM was funded by Marie Skłodowska-Curie Actions [grant agreement no. 713660—PRONKJEWAIL—H2020-MSCA-COFUND-2015 ] outside the submitted work. Publisher Copyright: © 2020 Sociedade Portuguesa de Pneumologia

PY - 2022/1/1

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N2 - Nitric oxide is a gas produced in the airways of asthmatic subjects and related to T2 inflammation. It can be measured as fractional nitric oxide (FeNO) in the exhaled air and used as a non-invasive, easy to evaluate, rapid marker. It is now widely used in many settings to determine airway inflammation. The aim of this narrative review is to report relationship between FeNO and the physiopathologic characteristics of asthmatic patients. Factors affecting FeNO levels have also been analysed as well as the impact of corticosteroid, target therapies and rehabilitation programs. Considering the availability of the test, spreading this methodology to low income countries has also been considered as a possibility for evaluating airway inflammation and monitoring adherence to inhaled corticosteroid therapy. PubMed data search has been performed restricted to English language papers. Research was limited to studies in adults unless studies in children were the only ones reported for a particular issue. This revision could be useful to summarize the role of FeNO in relation to asthma characteristics and help in the use of FeNO in different clinical settings particularly in low income countries.

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A snapshot of exhaled nitric oxide and asthma characteristics: experience from high to low income countries

Abstract

Keywords

ASJC Scopus subject areas

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