A RIDDle solved: Why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses

Eelco Van Anken; Andrea Orsi; Roberto Sitia

doi:10.1002/eji.201444461

A RIDDle solved: Why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses

Eelco Van Anken, Andrea Orsi, Roberto Sitia

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

As they commit to plasma cell differentiation, B lymphocytes must swiftly gear up to produce and secrete huge amounts of antibodies. To develop their secretory capacity, B cells exploit a signaling pathway that is employed by all eukaryotic cells in response to endoplasmic reticulum stress. An article by Benhamron et al. in this issue of the European Journal of Immunology, [Eur. J. Immunol. 2014. 44: 867-876] sheds new light on why an intact IRE1/XBP-1 signaling relay is central to orchestrate the full-blown expansion of the secretory machinery needed for massive antibody production.

Original language	English
Pages (from-to)	641-645
Number of pages	5
Journal	European Journal of Immunology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1002/eji.201444461
Publication status	Published - 2014

Keywords

Antibody production
IRE1
Plasma cells
Regulated IRE1-dependent decay (RIDD)
Unfolded protein response
XBP-1

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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abstract = "As they commit to plasma cell differentiation, B lymphocytes must swiftly gear up to produce and secrete huge amounts of antibodies. To develop their secretory capacity, B cells exploit a signaling pathway that is employed by all eukaryotic cells in response to endoplasmic reticulum stress. An article by Benhamron et al. in this issue of the European Journal of Immunology, [Eur. J. Immunol. 2014. 44: 867-876] sheds new light on why an intact IRE1/XBP-1 signaling relay is central to orchestrate the full-blown expansion of the secretory machinery needed for massive antibody production.",

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AU - Sitia, Roberto

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KW - Plasma cells

KW - Regulated IRE1-dependent decay (RIDD)

KW - Unfolded protein response

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A RIDDle solved: Why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses

Abstract

Keywords

ASJC Scopus subject areas

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