A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma

U. Veronesi, J. Adamus, C. Aubert, E. Bajetta, G. Beretta, G. Bonadonna, R. Bufalino, N. Cascinelli, G. Cocconi, J. Durand, J. De Marsillac, R. L. Ikonopisov, B. Kiss, F. Lejeune, R. MacKie, G. Madej, H. Mulder, Z. Mechl, G. W. Milton, A. MorabitoH. Peter, J. Priario, E. Paul, P. Rumke, R. Sertoli, R. Tomin

Research output: Contribution to journalArticlepeer-review


In a randomized trial of adjuvant chemotherapy, immunotherapy, or immunochemotherapy, 761 evaluable patients with pathological Stage II cutaneous melanoma anywhere on the body or with pathological State I melanoma of the trunk (Clark's level 3 to 5) were studied by the World Health Organization International Melanoma Group. Wide local exision and excisional regional lymphadenectomy alone were performed in 185 patients and the results were compared with those of surgery plus chemotherapy with dacarbazine (in 192 patients), surgery plus immunotherapy with bacille Calmette-Guerin vaccine (in 203), and surgery plus chemotherapy combined with immunotherapy (in 181). The rates of disease-free survival and overall survival at 36 months were 30.4±8.3 per cent (mean ±S.E.) and 41.6±10.0 per cent, respectively, after surgical treatment alone; 37.2±7.9 per cent and 46.5±8.3 per cent after surgery plus chemotherapy; 34.8±7.9 per cent and 48.7±8.7 per cent after surgery plus immunotherapy; and 33.6±7.9 per cent and 50.0±8.8 per cent after surgery plus a combination of chemotherapy and immunotherapy. None of the differences between groups was significant, and thus no effect of adjuvant therapy could be demonstrated in this study.

Original languageEnglish
Pages (from-to)913-916
Number of pages4
JournalNew England Journal of Medicine
Issue number15
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Medicine(all)


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