A possible predictive marker of progression for hepatocellular carcinoma

Michele di Stasio; Maria Grazia Volpe; Giovanni Colonna; Melissa Nazzaro; Miriam Polimeno; Stefania Scala; Giuseppe Castello; Susan Costantini

doi:10.3892/ol.2011.378

A possible predictive marker of progression for hepatocellular carcinoma

Michele di Stasio, Maria Grazia Volpe, Giovanni Colonna, Melissa Nazzaro, Miriam Polimeno, Stefania Scala, Giuseppe Castello, Susan Costantini

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.

Original language	English
Pages (from-to)	1247-1251
Number of pages	5
Journal	Oncology Letters
Volume	2
Issue number	6
DOIs	https://doi.org/10.3892/ol.2011.378
Publication status	Published - Nov 2011

Keywords

Atomic absorption spectrometry
HCC marker
Hepatocarcinoma prognosis
Selenium
Selenium binding protein-1

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3892/ol.2011.378

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title = "A possible predictive marker of progression for hepatocellular carcinoma",

abstract = "The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.",

keywords = "Atomic absorption spectrometry, HCC marker, Hepatocarcinoma prognosis, Selenium, Selenium binding protein-1",

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T1 - A possible predictive marker of progression for hepatocellular carcinoma

AU - di Stasio, Michele

AU - Volpe, Maria Grazia

AU - Colonna, Giovanni

AU - Nazzaro, Melissa

AU - Polimeno, Miriam

AU - Scala, Stefania

AU - Castello, Giuseppe

AU - Costantini, Susan

PY - 2011/11

Y1 - 2011/11

N2 - The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.

AB - The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.

KW - Atomic absorption spectrometry

KW - HCC marker

KW - Hepatocarcinoma prognosis

KW - Selenium

KW - Selenium binding protein-1

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A possible predictive marker of progression for hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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