A possible predictive marker of progression for hepatocellular carcinoma

Michele di Stasio, Maria Grazia Volpe, Giovanni Colonna, Melissa Nazzaro, Miriam Polimeno, Stefania Scala, Giuseppe Castello, Susan Costantini

Research output: Contribution to journalArticlepeer-review


The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.

Original languageEnglish
Pages (from-to)1247-1251
Number of pages5
JournalOncology Letters
Issue number6
Publication statusPublished - Nov 2011


  • Atomic absorption spectrometry
  • HCC marker
  • Hepatocarcinoma prognosis
  • Selenium
  • Selenium binding protein-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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