A new NOTCH3 mutation presenting as primary intracerebral haemorrhage

Luca Pradotto, Laura Orsi, Dino Daniele, Paola Caroppo, Danilo Lauro, Alessandra Milesi, Luigi Sellitti, Alessandro Mauro

Research output: Contribution to journalArticlepeer-review


Primary intracerebral haemorrhages (PICH) are defined as haemorrhages within the brain parenchyma in the absence of readily identifiable causes. CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary vascular disease and its mainly clinical manifestations are early-onset infarcts. Spontaneous lobar haematomas are a rare occurrence. We report a very unusual presentation of CADASIL in a 65 year-old man carrying a new NOTCH3 mutation. The clinical onset of the disease was related to an intracerebral haematoma following colon surgery and causing a delirium. In brief, our report suggests that CADASIL must be considered in patient with PICH.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Apr 15 2012


  • Cerebral haematoma
  • Heparin
  • Leukoarariosis
  • Notch3
  • PICH

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'A new NOTCH3 mutation presenting as primary intracerebral haemorrhage'. Together they form a unique fingerprint.

Cite this