A new mouse model of anti-GBM disease sheds light on maternal transfer of alloantibodies in glomerular disease

Marina Vivarelli; Francesco Emma

doi:10.1016/j.kint.2019.08.007

A new mouse model of anti-GBM disease sheds light on maternal transfer of alloantibodies in glomerular disease

Marina Vivarelli, Francesco Emma

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Membranous nephropathy and anti-glomerular basement membrane glomerulonephritis are characterized by the deposition of antibodies that recognize specific glomerular epitopes. These antibodies may develop in autoimmune diseases, after exposure to new antigens or after passive maternal transfer, such as in neonatal membranous nephropathy secondary to in utero transfer of anti-neutral endopeptidase protein Igs. In this issue of Kidney International, Abrahamson et al. reported a murine model of passive anti-glomerular basement membrane disease caused by antibody transfer from pregnant mice to their offspring.

Original language	English
Pages (from-to)	1272-1274
Number of pages	3
Journal	Kidney International
Volume	96
Issue number	6
DOIs	https://doi.org/10.1016/j.kint.2019.08.007
Publication status	Published - Dec 2019

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10.1016/j.kint.2019.08.007

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title = "A new mouse model of anti-GBM disease sheds light on maternal transfer of alloantibodies in glomerular disease",

abstract = "Membranous nephropathy and anti-glomerular basement membrane glomerulonephritis are characterized by the deposition of antibodies that recognize specific glomerular epitopes. These antibodies may develop in autoimmune diseases, after exposure to new antigens or after passive maternal transfer, such as in neonatal membranous nephropathy secondary to in utero transfer of anti-neutral endopeptidase protein Igs. In this issue of Kidney International, Abrahamson et al. reported a murine model of passive anti-glomerular basement membrane disease caused by antibody transfer from pregnant mice to their offspring.",

author = "Marina Vivarelli and Francesco Emma",

year = "2019",

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doi = "10.1016/j.kint.2019.08.007",

language = "English",

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journal = "Kidney International",

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AU - Vivarelli, Marina

AU - Emma, Francesco

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N2 - Membranous nephropathy and anti-glomerular basement membrane glomerulonephritis are characterized by the deposition of antibodies that recognize specific glomerular epitopes. These antibodies may develop in autoimmune diseases, after exposure to new antigens or after passive maternal transfer, such as in neonatal membranous nephropathy secondary to in utero transfer of anti-neutral endopeptidase protein Igs. In this issue of Kidney International, Abrahamson et al. reported a murine model of passive anti-glomerular basement membrane disease caused by antibody transfer from pregnant mice to their offspring.

AB - Membranous nephropathy and anti-glomerular basement membrane glomerulonephritis are characterized by the deposition of antibodies that recognize specific glomerular epitopes. These antibodies may develop in autoimmune diseases, after exposure to new antigens or after passive maternal transfer, such as in neonatal membranous nephropathy secondary to in utero transfer of anti-neutral endopeptidase protein Igs. In this issue of Kidney International, Abrahamson et al. reported a murine model of passive anti-glomerular basement membrane disease caused by antibody transfer from pregnant mice to their offspring.

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DO - 10.1016/j.kint.2019.08.007

M3 - Article

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SN - 0085-2538

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SP - 1272

EP - 1274

JO - Kidney International

JF - Kidney International

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ER -

A new mouse model of anti-GBM disease sheds light on maternal transfer of alloantibodies in glomerular disease

Abstract

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