A multicenter, case-control study on risk factors for antepartum stillbirth

Fabio Facchinetti, Salvatore Alberico, Chiara Benedetto, Irene Cetin, Sabrina Cozzolino, Gian Carlo Di Renzo, Cinzia Del Giovane, Francesca Ferrari, Federico Mecacci, Guido Menato, Andrea L. Tranquilli, Dante Baronciani

Research output: Contribution to journalArticlepeer-review


Objective. As the influence of socio-demographic variables, lifestyle and medical conditions on the epidemiology of stillbirth (SB) is modified by population features, we aimed at investigating the role played by these factors on the incidence of SB in a developed country. Study design. Multivariate logistic regression analysis (OR with 95% CI) was utilized in a prospective multicentre nested case-control study to compare in a 1:2 ratio stillborn of >22 weeks gestation with matched for gestational age live-born (LB) infants. Intrapartum SB were excluded. Results. Two hundred fifty-four consecutive SBs and 497 LBs were enrolled. Socio-demographic variables were equally distributed. Fetal malformations (7.96, 2.69-23.55), severe intrauterine growth restriction (IUGR) (birthweight ≤5 th %ile) (4.32, 2.27-8.24), BMI > 25 (2.87, 1.90-4.33), and preeclampsia (PE, 0.40, 0.21-0.77) were recognized as independent predictors for SB. At term, only BMI > 25 was associated with SB (7.70, 2.9-20.5). Conclusion. Fetal malformations, severe IUGR and maternal BMI > 25 were associated with a significant increase in the risk of SB; PE presented instead a protective role. Maternal BMI > 25 was the only risk factor for SB identified in term pregnancies.

Original languageEnglish
Pages (from-to)407-410
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number3
Publication statusPublished - Mar 2011


  • IUGR
  • obesity
  • preeclampsia
  • risk factors
  • Stillbirth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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