TY - JOUR
T1 - A multicenter, case-control study on risk factors for antepartum stillbirth
AU - Facchinetti, Fabio
AU - Alberico, Salvatore
AU - Benedetto, Chiara
AU - Cetin, Irene
AU - Cozzolino, Sabrina
AU - Di Renzo, Gian Carlo
AU - Del Giovane, Cinzia
AU - Ferrari, Francesca
AU - Mecacci, Federico
AU - Menato, Guido
AU - Tranquilli, Andrea L.
AU - Baronciani, Dante
PY - 2011/3
Y1 - 2011/3
N2 - Objective. As the influence of socio-demographic variables, lifestyle and medical conditions on the epidemiology of stillbirth (SB) is modified by population features, we aimed at investigating the role played by these factors on the incidence of SB in a developed country. Study design. Multivariate logistic regression analysis (OR with 95% CI) was utilized in a prospective multicentre nested case-control study to compare in a 1:2 ratio stillborn of >22 weeks gestation with matched for gestational age live-born (LB) infants. Intrapartum SB were excluded. Results. Two hundred fifty-four consecutive SBs and 497 LBs were enrolled. Socio-demographic variables were equally distributed. Fetal malformations (7.96, 2.69-23.55), severe intrauterine growth restriction (IUGR) (birthweight ≤5 th %ile) (4.32, 2.27-8.24), BMI > 25 (2.87, 1.90-4.33), and preeclampsia (PE, 0.40, 0.21-0.77) were recognized as independent predictors for SB. At term, only BMI > 25 was associated with SB (7.70, 2.9-20.5). Conclusion. Fetal malformations, severe IUGR and maternal BMI > 25 were associated with a significant increase in the risk of SB; PE presented instead a protective role. Maternal BMI > 25 was the only risk factor for SB identified in term pregnancies.
AB - Objective. As the influence of socio-demographic variables, lifestyle and medical conditions on the epidemiology of stillbirth (SB) is modified by population features, we aimed at investigating the role played by these factors on the incidence of SB in a developed country. Study design. Multivariate logistic regression analysis (OR with 95% CI) was utilized in a prospective multicentre nested case-control study to compare in a 1:2 ratio stillborn of >22 weeks gestation with matched for gestational age live-born (LB) infants. Intrapartum SB were excluded. Results. Two hundred fifty-four consecutive SBs and 497 LBs were enrolled. Socio-demographic variables were equally distributed. Fetal malformations (7.96, 2.69-23.55), severe intrauterine growth restriction (IUGR) (birthweight ≤5 th %ile) (4.32, 2.27-8.24), BMI > 25 (2.87, 1.90-4.33), and preeclampsia (PE, 0.40, 0.21-0.77) were recognized as independent predictors for SB. At term, only BMI > 25 was associated with SB (7.70, 2.9-20.5). Conclusion. Fetal malformations, severe IUGR and maternal BMI > 25 were associated with a significant increase in the risk of SB; PE presented instead a protective role. Maternal BMI > 25 was the only risk factor for SB identified in term pregnancies.
KW - IUGR
KW - obesity
KW - preeclampsia
KW - risk factors
KW - Stillbirth
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U2 - 10.3109/14767058.2010.496880
DO - 10.3109/14767058.2010.496880
M3 - Article
C2 - 20586545
AN - SCOPUS:79751471301
SN - 1476-7058
VL - 24
SP - 407
EP - 410
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 3
ER -