A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics

Matteo Lazzeroni; Federica Bellerba; Mariarosaria Calvello; Finlay Macrae; Aung Ko Win; Mark Jenkins; Davide Serrano; Monica Marabelli; Sara Cagnacci; Gianluca Tolva; Debora Macis; Sara Raimondi; Luca Mazzarella; Susanna Chiocca; Saverio Caini; Lucio Bertario; Bernardo Bonanni; Sara Gandini

doi:10.3390/nu13051736

A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics

Matteo Lazzeroni, Federica Bellerba, Mariarosaria Calvello, Finlay Macrae, Aung Ko Win, Mark Jenkins, Davide Serrano, Monica Marabelli, Sara Cagnacci, Gianluca Tolva, Debora Macis, Sara Raimondi, Luca Mazzarella, Susanna Chiocca, Saverio Caini, Lucio Bertario, Bernardo Bonanni, Sara Gandini

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific relationship between adiposity and CRC risk among patients with LS. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We investigated the causes of between-study heterogeneity and assessed the presence of publication bias. We were able to retrieve suitable data from four independent studies. We found a twofold risk of CRC in obese men compared to nonobese men (SRR = 2.09; 95%CI: 1.23-3.55, I2 = 33%), and no indication of publication bias (p = 0.13). No significantly increased risk due to obesity was found for women. A 49% increased CRC risk for obesity was found for subjects with an MLH1 mutation (SRR = 1.49; 95%CI: 1.11-1.99, I2 = 0%). These results confirm the different effects of sex on obesity and CRC risk and also support the public measures to reduce overweight in people with LS, particularly for men.

Original language	English
Journal	Nutrients
Volume	13
Issue number	5
DOIs	https://doi.org/10.3390/nu13051736
Publication status	Published - May 20 2021

Keywords

Adult
Colorectal Neoplasms/genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/genetics
Female
Genetic Predisposition to Disease/genetics
Humans
Male
MutL Protein Homolog 1/genetics
Mutation
Obesity/genetics
Risk
Sex Factors

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10.3390/nu13051736

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Lazzeroni, M., Bellerba, F., Calvello, M., Macrae, F., Win, A. K., Jenkins, M., Serrano, D., Marabelli, M., Cagnacci, S., Tolva, G., Macis, D., Raimondi, S., Mazzarella, L., Chiocca, S., Caini, S., Bertario, L., Bonanni, B., & Gandini, S. (2021). A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics. Nutrients, 13(5). https://doi.org/10.3390/nu13051736

Lazzeroni, M , Bellerba, F , Calvello, M, Macrae, F, Win, AK, Jenkins, M, Serrano, D , Marabelli, M, Cagnacci, S, Tolva, G , Macis, D , Raimondi, S , Mazzarella, L , Chiocca, S, Caini, S, Bertario, L, Bonanni, B & Gandini, S 2021, 'A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics', Nutrients, vol. 13, no. 5. https://doi.org/10.3390/nu13051736

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abstract = "There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific relationship between adiposity and CRC risk among patients with LS. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We investigated the causes of between-study heterogeneity and assessed the presence of publication bias. We were able to retrieve suitable data from four independent studies. We found a twofold risk of CRC in obese men compared to nonobese men (SRR = 2.09; 95%CI: 1.23-3.55, I2 = 33%), and no indication of publication bias (p = 0.13). No significantly increased risk due to obesity was found for women. A 49% increased CRC risk for obesity was found for subjects with an MLH1 mutation (SRR = 1.49; 95%CI: 1.11-1.99, I2 = 0%). These results confirm the different effects of sex on obesity and CRC risk and also support the public measures to reduce overweight in people with LS, particularly for men.",

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AU - Lazzeroni, Matteo

AU - Bellerba, Federica

AU - Calvello, Mariarosaria

AU - Macrae, Finlay

AU - Win, Aung Ko

AU - Jenkins, Mark

AU - Serrano, Davide

AU - Marabelli, Monica

AU - Cagnacci, Sara

AU - Tolva, Gianluca

AU - Macis, Debora

AU - Raimondi, Sara

AU - Mazzarella, Luca

AU - Chiocca, Susanna

AU - Caini, Saverio

AU - Bertario, Lucio

AU - Bonanni, Bernardo

AU - Gandini, Sara

PY - 2021/5/20

Y1 - 2021/5/20

N2 - There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific relationship between adiposity and CRC risk among patients with LS. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We investigated the causes of between-study heterogeneity and assessed the presence of publication bias. We were able to retrieve suitable data from four independent studies. We found a twofold risk of CRC in obese men compared to nonobese men (SRR = 2.09; 95%CI: 1.23-3.55, I2 = 33%), and no indication of publication bias (p = 0.13). No significantly increased risk due to obesity was found for women. A 49% increased CRC risk for obesity was found for subjects with an MLH1 mutation (SRR = 1.49; 95%CI: 1.11-1.99, I2 = 0%). These results confirm the different effects of sex on obesity and CRC risk and also support the public measures to reduce overweight in people with LS, particularly for men.

AB - There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific relationship between adiposity and CRC risk among patients with LS. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We investigated the causes of between-study heterogeneity and assessed the presence of publication bias. We were able to retrieve suitable data from four independent studies. We found a twofold risk of CRC in obese men compared to nonobese men (SRR = 2.09; 95%CI: 1.23-3.55, I2 = 33%), and no indication of publication bias (p = 0.13). No significantly increased risk due to obesity was found for women. A 49% increased CRC risk for obesity was found for subjects with an MLH1 mutation (SRR = 1.49; 95%CI: 1.11-1.99, I2 = 0%). These results confirm the different effects of sex on obesity and CRC risk and also support the public measures to reduce overweight in people with LS, particularly for men.

KW - Adult

KW - Colorectal Neoplasms/genetics

KW - Colorectal Neoplasms, Hereditary Nonpolyposis/genetics

KW - Female

KW - Genetic Predisposition to Disease/genetics

KW - Humans

KW - Male

KW - MutL Protein Homolog 1/genetics

KW - Mutation

KW - Obesity/genetics

KW - Risk

KW - Sex Factors

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DO - 10.3390/nu13051736

M3 - Article

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SN - 2072-6643

VL - 13

JO - Nutrients

JF - Nutrients

IS - 5

ER -

A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics

Abstract

Keywords

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