A historical perspective on milestones in multiple myeloma research

Domenico Ribatti

Research output: Contribution to journalReview articlepeer-review


The first well-documented case of multiple myeloma was reported in 1844 by Samuel Solly. In this article, the author presents a historical review of the disease. In particular, the review is focused on the main steps, including the definition of Bence Jones proteinuria, the characterization of tumoral plasma cells and serum globulins, and the fundamental contribution of Jan Waldenstrom. Finally, treatment of multiple myeloma, as well as the development of new agents, is discussed.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalEuropean Journal of Haematology
Issue number3
Publication statusPublished - Mar 1 2018


  • hematology
  • history of medicine
  • multiple myeloma
  • tumor growth

ASJC Scopus subject areas

  • Hematology


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