A functional interplay between IGF-1 and adiponectin

Stefania Orrù, Ersilia Nigro, Annalisa Mandola, Andreina Alfieri, Pasqualina Buono, Aurora Daniele, Annamaria Mancini, Esther Imperlini

Research output: Contribution to journalReview articlepeer-review


A functional relationship is suggested between two well-known protein hormones, insulin-like growth factor 1 (IGF-1) and adiponectin. In the last two decades in fact, different experimental evidence has indicated a non-random link between them. Here, we describe briefly the IGF-1 and adiponectin systems, and we then focus on their putative interplay in relation to several pathological conditions, including obesity, diabetes, insulin resistance, cardiovascular disease, and cancer. Although the existing studies are hardly comparable, they definitely indicate a functional connection between these two protein hormones. In conclusion, the current knowledge strongly encourages further research into the common, as well as novel, mechanisms through which IGF-1 and adiponectin exert their concerted action.

Original languageEnglish
Article number2145
JournalInternational Journal of Molecular Sciences
Issue number10
Publication statusPublished - Oct 14 2017


  • Adiponectin
  • Cancer
  • Cardiovascular disease
  • Diabetes
  • Growth hormone (GH)
  • Heart failure
  • Insulin resistance
  • Insulin-like growth factor-1 (IGF-1)
  • Obesity

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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