A drug from the sea that strikes tumor-associated macrophages

Paola Allavena; Giovanni Germano; Cristina Belgiovine; Maurizio D'Incalci; Alberto Mantovani

doi:10.4161/onci.24614

A drug from the sea that strikes tumor-associated macrophages

Paola Allavena, Giovanni Germano, Cristina Belgiovine, Maurizio D'Incalci, Alberto Mantovani

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor-associated macrophages (TAMs) and other myeloid cells that infiltrate neoplastic lesions promote tumor progression and are associated with poor patient prognosis. We have recently demonstrated that trabectedin, a licensed and commercially available anticancer agent, is selectively cytotoxic for TAMs and their circulating precursors (monocytes). The macrophage-depleting effect of trabectedin is a key component of its antitumor activity.

Original language	English
Article number	e24614
Journal	OncoImmunology
Volume	2
Issue number	6
DOIs	https://doi.org/10.4161/onci.24614
Publication status	Published - Jun 2013

Keywords

Angiogenesis
Chemotherapy
Marine drug
Micro-environment
Tumor-associated macrophages

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

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10.4161/onci.24614

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title = "A drug from the sea that strikes tumor-associated macrophages",

abstract = "Tumor-associated macrophages (TAMs) and other myeloid cells that infiltrate neoplastic lesions promote tumor progression and are associated with poor patient prognosis. We have recently demonstrated that trabectedin, a licensed and commercially available anticancer agent, is selectively cytotoxic for TAMs and their circulating precursors (monocytes). The macrophage-depleting effect of trabectedin is a key component of its antitumor activity.",

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AU - Allavena, Paola

AU - Germano, Giovanni

AU - Belgiovine, Cristina

AU - D'Incalci, Maurizio

AU - Mantovani, Alberto

PY - 2013/6

Y1 - 2013/6

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AB - Tumor-associated macrophages (TAMs) and other myeloid cells that infiltrate neoplastic lesions promote tumor progression and are associated with poor patient prognosis. We have recently demonstrated that trabectedin, a licensed and commercially available anticancer agent, is selectively cytotoxic for TAMs and their circulating precursors (monocytes). The macrophage-depleting effect of trabectedin is a key component of its antitumor activity.

KW - Angiogenesis

KW - Chemotherapy

KW - Marine drug

KW - Micro-environment

KW - Tumor-associated macrophages

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ER -

A drug from the sea that strikes tumor-associated macrophages

Abstract

Keywords

ASJC Scopus subject areas

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