A critical appraisal of systemic treatment options for metastatic non-clear cell renal cell carcinoma

Salima Ismail, Malek Meskawi, Jens Hansen, Marco Bianchi, Zhe Tian, Mathieu Latour, Markus Graefen, Francesco Montorsi, Quoc Dien Trinh, Paul Perrotte, Pierre I. Karakiewicz, Maxine Sun

Research output: Contribution to journalArticlepeer-review


Current guidelines provide most support for the use of temsirolimus in first line therapy for metastatic non-clear cell renal cell carcinoma (nccRCC). However, this recommendation is based on scant level 2a evidence. The objective of this review is to examine the evidence supporting first line temsirolimus use in patients with metastatic nccRCC as well as alternative first line treatment options. Six studies, that assessed the efficacy of five agents qualified for inclusion. Among recognized treatment options for metastatic nccRCC, mean weighted progression free survival values of 7.9 months for temsirolimus vs. 7.3 for sunitinib vs. 8.5 months for sorafenib vs. ≈4.1 months for erlotinib were recorded based on data from 10, 74, 33 and 51 patients respectively. In conclusion, the data supporting first line temsirolimus for metastatic nccRCC are based on a small patient sample. Sunitinib's efficacy is similar to that of temsirolimus but is based on a bigger patient sample that originates from phase II studies.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Issue number1
Publication statusPublished - 2014


  • Chromophobe
  • Metastatic
  • Non-clear cell
  • Papillary
  • Renal cell carcinoma
  • Sorafenib
  • Sunitinib
  • Systemic therapy
  • Targeted therapy
  • Temsirolimus

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology


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