A critical appraisal of systemic treatment options for metastatic non-clear cell renal cell carcinoma

Salima Ismail; Malek Meskawi; Jens Hansen; Marco Bianchi; Zhe Tian; Mathieu Latour; Markus Graefen; Francesco Montorsi; Quoc Dien Trinh; Paul Perrotte; Pierre I. Karakiewicz; Maxine Sun

doi:10.1016/j.critrevonc.2013.12.003

A critical appraisal of systemic treatment options for metastatic non-clear cell renal cell carcinoma

Salima Ismail, Malek Meskawi, Jens Hansen, Marco Bianchi, Zhe Tian, Mathieu Latour, Markus Graefen, Francesco Montorsi, Quoc Dien Trinh, Paul Perrotte, Pierre I. Karakiewicz, Maxine Sun

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Current guidelines provide most support for the use of temsirolimus in first line therapy for metastatic non-clear cell renal cell carcinoma (nccRCC). However, this recommendation is based on scant level 2a evidence. The objective of this review is to examine the evidence supporting first line temsirolimus use in patients with metastatic nccRCC as well as alternative first line treatment options. Six studies, that assessed the efficacy of five agents qualified for inclusion. Among recognized treatment options for metastatic nccRCC, mean weighted progression free survival values of 7.9 months for temsirolimus vs. 7.3 for sunitinib vs. 8.5 months for sorafenib vs. ≈4.1 months for erlotinib were recorded based on data from 10, 74, 33 and 51 patients respectively. In conclusion, the data supporting first line temsirolimus for metastatic nccRCC are based on a small patient sample. Sunitinib's efficacy is similar to that of temsirolimus but is based on a bigger patient sample that originates from phase II studies.

Original language	English
Pages (from-to)	49-57
Number of pages	9
Journal	Critical Reviews in Oncology/Hematology
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/j.critrevonc.2013.12.003
Publication status	Published - 2014

Keywords

Chromophobe
Metastatic
Non-clear cell
Papillary
Renal cell carcinoma
Sorafenib
Sunitinib
Systemic therapy
Targeted therapy
Temsirolimus

ASJC Scopus subject areas

Oncology
Hematology
Geriatrics and Gerontology

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10.1016/j.critrevonc.2013.12.003

Cite this

Ismail, S., Meskawi, M., Hansen, J., Bianchi, M., Tian, Z., Latour, M., Graefen, M., Montorsi, F., Trinh, Q. D., Perrotte, P., Karakiewicz, P. I., & Sun, M. (2014). A critical appraisal of systemic treatment options for metastatic non-clear cell renal cell carcinoma. Critical Reviews in Oncology/Hematology, 90(1), 49-57. https://doi.org/10.1016/j.critrevonc.2013.12.003

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abstract = "Current guidelines provide most support for the use of temsirolimus in first line therapy for metastatic non-clear cell renal cell carcinoma (nccRCC). However, this recommendation is based on scant level 2a evidence. The objective of this review is to examine the evidence supporting first line temsirolimus use in patients with metastatic nccRCC as well as alternative first line treatment options. Six studies, that assessed the efficacy of five agents qualified for inclusion. Among recognized treatment options for metastatic nccRCC, mean weighted progression free survival values of 7.9 months for temsirolimus vs. 7.3 for sunitinib vs. 8.5 months for sorafenib vs. ≈4.1 months for erlotinib were recorded based on data from 10, 74, 33 and 51 patients respectively. In conclusion, the data supporting first line temsirolimus for metastatic nccRCC are based on a small patient sample. Sunitinib's efficacy is similar to that of temsirolimus but is based on a bigger patient sample that originates from phase II studies.",

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author = "Salima Ismail and Malek Meskawi and Jens Hansen and Marco Bianchi and Zhe Tian and Mathieu Latour and Markus Graefen and Francesco Montorsi and Trinh, {Quoc Dien} and Paul Perrotte and Karakiewicz, {Pierre I.} and Maxine Sun",

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AU - Ismail, Salima

AU - Meskawi, Malek

AU - Hansen, Jens

AU - Bianchi, Marco

AU - Tian, Zhe

AU - Latour, Mathieu

AU - Graefen, Markus

AU - Montorsi, Francesco

AU - Trinh, Quoc Dien

AU - Perrotte, Paul

AU - Karakiewicz, Pierre I.

AU - Sun, Maxine

PY - 2014

Y1 - 2014

N2 - Current guidelines provide most support for the use of temsirolimus in first line therapy for metastatic non-clear cell renal cell carcinoma (nccRCC). However, this recommendation is based on scant level 2a evidence. The objective of this review is to examine the evidence supporting first line temsirolimus use in patients with metastatic nccRCC as well as alternative first line treatment options. Six studies, that assessed the efficacy of five agents qualified for inclusion. Among recognized treatment options for metastatic nccRCC, mean weighted progression free survival values of 7.9 months for temsirolimus vs. 7.3 for sunitinib vs. 8.5 months for sorafenib vs. ≈4.1 months for erlotinib were recorded based on data from 10, 74, 33 and 51 patients respectively. In conclusion, the data supporting first line temsirolimus for metastatic nccRCC are based on a small patient sample. Sunitinib's efficacy is similar to that of temsirolimus but is based on a bigger patient sample that originates from phase II studies.

AB - Current guidelines provide most support for the use of temsirolimus in first line therapy for metastatic non-clear cell renal cell carcinoma (nccRCC). However, this recommendation is based on scant level 2a evidence. The objective of this review is to examine the evidence supporting first line temsirolimus use in patients with metastatic nccRCC as well as alternative first line treatment options. Six studies, that assessed the efficacy of five agents qualified for inclusion. Among recognized treatment options for metastatic nccRCC, mean weighted progression free survival values of 7.9 months for temsirolimus vs. 7.3 for sunitinib vs. 8.5 months for sorafenib vs. ≈4.1 months for erlotinib were recorded based on data from 10, 74, 33 and 51 patients respectively. In conclusion, the data supporting first line temsirolimus for metastatic nccRCC are based on a small patient sample. Sunitinib's efficacy is similar to that of temsirolimus but is based on a bigger patient sample that originates from phase II studies.

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KW - Renal cell carcinoma

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KW - Systemic therapy

KW - Targeted therapy

KW - Temsirolimus

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A critical appraisal of systemic treatment options for metastatic non-clear cell renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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