TY - JOUR
T1 - A common neural substrate for number comparison, hand reaching and grasping
T2 - A SDM-PSI meta-analysis of neuroimaging studies
AU - Ranzini, Mariagrazia
AU - Scarpazza, Cristina
AU - Radua, Joaquim
AU - Cutini, Simone
AU - Semenza, Carlo
AU - Zorzi, Marco
N1 - Funding Information:
This work was funded by the European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie Grant 839394 (to M.R.), and it was carried out within the scope of the research program Dipartimenti di Eccellenza (art.1, commi 314-337 legge 232/2016), which was supported by a grant from MIUR to the Department of General Psychology, University of Padua. MR thanks all the authors who have kindly provided additional information on their studies. Also, MR is particularly grateful to Simona Monaco (University of Trento) for her interest and insightful comments on this work.
Funding Information:
This work was funded by the European Union's Horizon 2020 research and innovation program under Marie Sk?odowska-Curie Grant 839394 (to M.R.), and it was carried out within the scope of the research program Dipartimenti di Eccellenza (art.1, commi 314-337 legge 232/2016), which was supported by a grant from MIUR to the Department of General Psychology, University of Padua. MR thanks all the authors who have kindly provided additional information on their studies. Also, MR is particularly grateful to Simona Monaco (University of Trento) for her interest and insightful comments on this work.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/1/11
Y1 - 2022/1/11
N2 - The reliance of number processing on sensorimotor mechanisms involved in hand action has been extensively documented by behavioural studies. Nonetheless, where and how the computations of number and hand action interact in the brain has received limited attention. In this study we investigated the brain networks underlying symbolic number comparison and the hand action of reaching and grasping, capitalizing on functional imaging studies meta-analyzed with the seed-based d mapping with permutation of subject images meta-analytic method (SDM-PSI). The main objective was to test whether and to what extent symbolic number processing recruits the same sensorimotor network involved in the hand action of reaching and grasping. We included 42 studies (756 participants) adopting symbolic number comparison tasks and 58 studies (867 participants) investigating hand reaching and hand grasping. The conjunction analysis of brain networks common to number processing, reaching, and grasping revealed spatial convergence over frontoparietal areas. Specifically, four clusters were identified, in and around the left and right intraparietal sulci, in the left precentral gyrus, and in the supplementary motor area. The degree of overlap was extensive, since the reach/grasp network mostly included the number areas. A qualitative analysis of functional characterization capitalizing on the Neurosynth database depicted a strong multifunctionality of the regions of overlap between numbers and hand action: these brain areas were also associated to a variety of functions within the domains of memory and imagery, visuospatial attention, and language. Overall, these results characterize the neuroanatomical substrate of the interaction between reaching, grasping, and symbolic number comparison.
AB - The reliance of number processing on sensorimotor mechanisms involved in hand action has been extensively documented by behavioural studies. Nonetheless, where and how the computations of number and hand action interact in the brain has received limited attention. In this study we investigated the brain networks underlying symbolic number comparison and the hand action of reaching and grasping, capitalizing on functional imaging studies meta-analyzed with the seed-based d mapping with permutation of subject images meta-analytic method (SDM-PSI). The main objective was to test whether and to what extent symbolic number processing recruits the same sensorimotor network involved in the hand action of reaching and grasping. We included 42 studies (756 participants) adopting symbolic number comparison tasks and 58 studies (867 participants) investigating hand reaching and hand grasping. The conjunction analysis of brain networks common to number processing, reaching, and grasping revealed spatial convergence over frontoparietal areas. Specifically, four clusters were identified, in and around the left and right intraparietal sulci, in the left precentral gyrus, and in the supplementary motor area. The degree of overlap was extensive, since the reach/grasp network mostly included the number areas. A qualitative analysis of functional characterization capitalizing on the Neurosynth database depicted a strong multifunctionality of the regions of overlap between numbers and hand action: these brain areas were also associated to a variety of functions within the domains of memory and imagery, visuospatial attention, and language. Overall, these results characterize the neuroanatomical substrate of the interaction between reaching, grasping, and symbolic number comparison.
KW - Hand grasping
KW - Hand reaching
KW - Meta-analysis
KW - Number comparison
KW - Numerical cognition
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U2 - 10.1016/j.cortex.2021.12.007
DO - 10.1016/j.cortex.2021.12.007
M3 - Article
AN - SCOPUS:85123952301
SN - 0010-9452
VL - 148
SP - 31
EP - 67
JO - Cortex
JF - Cortex
ER -