TY - JOUR
T1 - A case of Vogt-Koyanagi-Harada-like uveitis secondary to dabrafenib/trametinib therapy for advanced melanoma
AU - Brambati, Maria
AU - Giuffrè, Chiara
AU - Marchese, Alessandro
AU - Bandello, Francesco
AU - Modorati, Giulio Maria
AU - Miserocchi, Elisabetta
N1 - Nota Biblioteca: Case Report
Publisher Copyright:
© The Author(s) 2020.
PY - 2022/1
Y1 - 2022/1
N2 - We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib/Trametinib, developed a severe acute panuveitis with granulomatous anterior uveitis and multiple serous retinal detachments. The ocular inflammatory reaction was classified as a bilateral Vogt-Koyanagi-Harada disease. Intraocular inflammation resolved after discontinuation of chemotherapeutic agents and aggressive topical and systemic corticosteroid therapy. The present case outlines the importance of recognizing VKH-like syndrome as a possible consequence of therapy with dabrafenib and trametinib.
AB - We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib/Trametinib, developed a severe acute panuveitis with granulomatous anterior uveitis and multiple serous retinal detachments. The ocular inflammatory reaction was classified as a bilateral Vogt-Koyanagi-Harada disease. Intraocular inflammation resolved after discontinuation of chemotherapeutic agents and aggressive topical and systemic corticosteroid therapy. The present case outlines the importance of recognizing VKH-like syndrome as a possible consequence of therapy with dabrafenib and trametinib.
KW - choroidal/retinal inflammation
KW - Immunology
KW - panuveitis
KW - pharmacology
KW - RETINA
KW - systemic drug retinal toxicity
KW - UVEA
KW - UVEITIS
UR - http://www.scopus.com/inward/record.url?scp=85091750536&partnerID=8YFLogxK
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U2 - 10.1177/1120672120962044
DO - 10.1177/1120672120962044
M3 - Article
C2 - 32998540
AN - SCOPUS:85091750536
SN - 1120-6721
VL - 32
SP - NP109-NP113
JO - European Journal of Ophthalmology
JF - European Journal of Ophthalmology
IS - 1
ER -