A Case of Coloboma in a Newborn to a Woman Taking Mycophenolate Mofetil in Pregnancy After Kidney Transplantation

M. Framarino dei Malatesta; B. Rocca; T. Gentile; T. Hadjistilianou; M. Borri; S. de Francesco; F. Pisani; A. Famulari

doi:10.1016/j.transproceed.2009.03.088

A Case of Coloboma in a Newborn to a Woman Taking Mycophenolate Mofetil in Pregnancy After Kidney Transplantation

M. Framarino dei Malatesta, B. Rocca, T. Gentile, T. Hadjistilianou, M. Borri, S. de Francesco, F. Pisani, A. Famulari

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, mycophenolate mofetil (MMF) has been introduced in the immunosuppressive strategy after kidney transplantation. Recently, the existence of a MMF associated embriopathy has been hypothesized, namely, multiple craniofacial malformations. Only 1 report has described chorioretinal coloboma. We report a case of woman who used MMF throughout pregnancy after kidney transplantation. Her newborn developed coloboma of the right eye associated with an ocular cyst without any other malformation. The other drugs used by our patient are not considered teratogenic. Therefore, it seems reasonable to conclude a causal relationship between MMF and the malformation observed in this newborn.

Original language	English
Pages (from-to)	1407-1409
Number of pages	3
Journal	Transplantation Proceedings
Volume	41
Issue number	4
DOIs	https://doi.org/10.1016/j.transproceed.2009.03.088
Publication status	Published - May 2009

ASJC Scopus subject areas

Surgery
Transplantation
Medicine(all)

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10.1016/j.transproceed.2009.03.088

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title = "A Case of Coloboma in a Newborn to a Woman Taking Mycophenolate Mofetil in Pregnancy After Kidney Transplantation",

abstract = "Recently, mycophenolate mofetil (MMF) has been introduced in the immunosuppressive strategy after kidney transplantation. Recently, the existence of a MMF associated embriopathy has been hypothesized, namely, multiple craniofacial malformations. Only 1 report has described chorioretinal coloboma. We report a case of woman who used MMF throughout pregnancy after kidney transplantation. Her newborn developed coloboma of the right eye associated with an ocular cyst without any other malformation. The other drugs used by our patient are not considered teratogenic. Therefore, it seems reasonable to conclude a causal relationship between MMF and the malformation observed in this newborn.",

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AU - dei Malatesta, M. Framarino

AU - Rocca, B.

AU - Gentile, T.

AU - Hadjistilianou, T.

AU - Borri, M.

AU - de Francesco, S.

AU - Pisani, F.

AU - Famulari, A.

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AB - Recently, mycophenolate mofetil (MMF) has been introduced in the immunosuppressive strategy after kidney transplantation. Recently, the existence of a MMF associated embriopathy has been hypothesized, namely, multiple craniofacial malformations. Only 1 report has described chorioretinal coloboma. We report a case of woman who used MMF throughout pregnancy after kidney transplantation. Her newborn developed coloboma of the right eye associated with an ocular cyst without any other malformation. The other drugs used by our patient are not considered teratogenic. Therefore, it seems reasonable to conclude a causal relationship between MMF and the malformation observed in this newborn.

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A Case of Coloboma in a Newborn to a Woman Taking Mycophenolate Mofetil in Pregnancy After Kidney Transplantation

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