A bioimaging integration system implemented for neurological applications

G. Rizzo, M. C. Gilardi, A. Prinster, G. Lucignani, V. Bettinardi, F. Triulzi, A. Cardaioli, S. Cerutti, F. Fazio

Research output: Contribution to journalArticlepeer-review


A system aimed at the management and fusion of multimodal biomedical images, including X-ray computed tomography, magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography, has been implemented for neurological applications. This bioimaging integration system (BIS) consists of a network for image transmission from acquisition machines to dedicated image processing workstations, a software library for image standardization, and an image registration technique to project multimodal volumetric images into a common reference space. The registration procedure was evaluated in MRI/PET correlation studies, in which misalignment errors of 2.6 mm in the xy transaxial plane and 3.4 mm along the z axis were found. BIS has been validated for the anatomical-functional correlation analysis of MRI and PET images in neurological research protocols and clinical studies.

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalJournal of nuclear biology and medicine (Turin, Italy : 1991)
Issue number4
Publication statusPublished - 1994


  • anatomofunctional correlation
  • image fusion
  • tomographic image

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'A bioimaging integration system implemented for neurological applications'. Together they form a unique fingerprint.

Cite this