2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells

Silvia Mari; Chiara Invernizzi; Andrea Spitaleri; Luca Alberici; Michela Ghitti; Claudio Bordignon; Catia Traversari; Gian Paolo Rizzardi; Giovanna Musco

doi:10.1002/anie.200905941

2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells

Silvia Mari, Chiara Invernizzi, Andrea Spitaleri, Luca Alberici, Michela Ghitti, Claudio Bordignon, Catia Traversari, Gian Paolo Rizzardi, Giovanna Musco

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Cell mates: Various ligand-receptor interactions in different human cancer cell lines were probed directly by two-dimensional transferred-NOE spectroscopy (see picture) to prove recognition specificity and determine an affinity ranking of several ligands.

Original language	English
Pages (from-to)	1071-1074
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	6
DOIs	https://doi.org/10.1002/anie.200905941
Publication status	Published - Feb 1 2010

Keywords

Drug design
Integrins
Nmr spectroscopy
Protein-ligand interactions

ASJC Scopus subject areas

Chemistry(all)
Catalysis

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10.1002/anie.200905941

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title = "2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells",

abstract = "(Figure Presented) Cell mates: Various ligand-receptor interactions in different human cancer cell lines were probed directly by two-dimensional transferred-NOE spectroscopy (see picture) to prove recognition specificity and determine an affinity ranking of several ligands.",

keywords = "Drug design, Integrins, Nmr spectroscopy, Protein-ligand interactions",

author = "Silvia Mari and Chiara Invernizzi and Andrea Spitaleri and Luca Alberici and Michela Ghitti and Claudio Bordignon and Catia Traversari and Rizzardi, {Gian Paolo} and Giovanna Musco",

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AU - Mari, Silvia

AU - Invernizzi, Chiara

AU - Spitaleri, Andrea

AU - Alberici, Luca

AU - Ghitti, Michela

AU - Bordignon, Claudio

AU - Traversari, Catia

AU - Rizzardi, Gian Paolo

AU - Musco, Giovanna

PY - 2010/2/1

Y1 - 2010/2/1

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KW - Integrins

KW - Nmr spectroscopy

KW - Protein-ligand interactions

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2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells

Abstract

Keywords

ASJC Scopus subject areas

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