18F-FDG PET/CT in Labrune Syndrome

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A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were observed at MRI and CT brain images. Generalized wave abnormalities were also visible at electroencephalogram. Functional brain imaging performed with F-FDG PET/CT demonstrated a decreased glucose metabolism in impaired brain regions, in accordance with MRI findings. Genetic testing confirmed a mutation of SNORD118.

Original languageEnglish
Pages (from-to)e439-e440
JournalClinical Nuclear Medicine
Issue number10
Publication statusPublished - Oct 1 2020

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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