TY - JOUR
T1 - 18F-FDG PET/CT in Labrune Syndrome
AU - Cuzzocrea, Marco
AU - Florimonte, Luigia
AU - Scola, Elisa
AU - Benti, Riccardo
AU - Castellani, Massimo
PY - 2020/10/1
Y1 - 2020/10/1
N2 - A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were observed at MRI and CT brain images. Generalized wave abnormalities were also visible at electroencephalogram. Functional brain imaging performed with F-FDG PET/CT demonstrated a decreased glucose metabolism in impaired brain regions, in accordance with MRI findings. Genetic testing confirmed a mutation of SNORD118.
AB - A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were observed at MRI and CT brain images. Generalized wave abnormalities were also visible at electroencephalogram. Functional brain imaging performed with F-FDG PET/CT demonstrated a decreased glucose metabolism in impaired brain regions, in accordance with MRI findings. Genetic testing confirmed a mutation of SNORD118.
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U2 - 10.1097/RLU.0000000000003199
DO - 10.1097/RLU.0000000000003199
M3 - Article
C2 - 32657880
AN - SCOPUS:85090505815
SN - 0363-9762
VL - 45
SP - e439-e440
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
IS - 10
ER -