18F-FAZA PET imaging in tumor hypoxia: A focus on high-grade glioma

Paola Mapelli; Maria Picchio

doi:10.1177/1724600820905715

18F-FAZA PET imaging in tumor hypoxia: A focus on high-grade glioma

Research output: Contribution to journal › Article › peer-review

Abstract

The presence of hypoxia is a typical feature of solid tumors and has been identified in many neoplasms, favouring the survival of malignant cells in a hostile environment and the expression of an aggressive phenotype. Malignant brain tumors have large proportions of hypoxic tissue, thus contributing to resistance to radiation and chemotherapy. Positron emission tomography (PET) is an attractive technique to gain a non-invasive assessment of tumor hypoxia within the whole tumor, with 18F-fluoromisonidazole (18F-FMISO) and 18F-flouroazomycin arabinoside (18F-FAZA) being the most promising radiotracers. In this short review, we aim to discuss the available clinical studies focused on the use of 18F-FAZA PET/computed tomography in patients affected by high-grade glioma.

Original language	English
Pages (from-to)	42-46
Number of pages	5
Journal	International Journal of Biological Markers
Volume	35
Issue number	1_suppl
DOIs	https://doi.org/10.1177/1724600820905715
Publication status	Published - 2020

Keywords

18F-FAZA
brain tumor
glioma
hypoxia
PET/CT
PET/MRI

ASJC Scopus subject areas

Pathology and Forensic Medicine
Oncology
Clinical Biochemistry
Cancer Research

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10.1177/1724600820905715

Cite this

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title = "18F-FAZA PET imaging in tumor hypoxia: A focus on high-grade glioma",

abstract = "The presence of hypoxia is a typical feature of solid tumors and has been identified in many neoplasms, favouring the survival of malignant cells in a hostile environment and the expression of an aggressive phenotype. Malignant brain tumors have large proportions of hypoxic tissue, thus contributing to resistance to radiation and chemotherapy. Positron emission tomography (PET) is an attractive technique to gain a non-invasive assessment of tumor hypoxia within the whole tumor, with 18F-fluoromisonidazole (18F-FMISO) and 18F-flouroazomycin arabinoside (18F-FAZA) being the most promising radiotracers. In this short review, we aim to discuss the available clinical studies focused on the use of 18F-FAZA PET/computed tomography in patients affected by high-grade glioma.",

keywords = "18F-FAZA, brain tumor, glioma, hypoxia, PET/CT, PET/MRI",

author = "Paola Mapelli and Maria Picchio",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The present work was supported by the Italian Association for Cancer Research (grant IG 2014 Id.1524; EudraCT: 2015-000679-28). Publisher Copyright: {\textcopyright} The Author(s) 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

doi = "10.1177/1724600820905715",

language = "English",

volume = "35",

pages = "42--46",

journal = "International Journal of Biological Markers",

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T1 - 18F-FAZA PET imaging in tumor hypoxia

T2 - A focus on high-grade glioma

AU - Mapelli, Paola

AU - Picchio, Maria

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The present work was supported by the Italian Association for Cancer Research (grant IG 2014 Id.1524; EudraCT: 2015-000679-28). Publisher Copyright: © The Author(s) 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - The presence of hypoxia is a typical feature of solid tumors and has been identified in many neoplasms, favouring the survival of malignant cells in a hostile environment and the expression of an aggressive phenotype. Malignant brain tumors have large proportions of hypoxic tissue, thus contributing to resistance to radiation and chemotherapy. Positron emission tomography (PET) is an attractive technique to gain a non-invasive assessment of tumor hypoxia within the whole tumor, with 18F-fluoromisonidazole (18F-FMISO) and 18F-flouroazomycin arabinoside (18F-FAZA) being the most promising radiotracers. In this short review, we aim to discuss the available clinical studies focused on the use of 18F-FAZA PET/computed tomography in patients affected by high-grade glioma.

AB - The presence of hypoxia is a typical feature of solid tumors and has been identified in many neoplasms, favouring the survival of malignant cells in a hostile environment and the expression of an aggressive phenotype. Malignant brain tumors have large proportions of hypoxic tissue, thus contributing to resistance to radiation and chemotherapy. Positron emission tomography (PET) is an attractive technique to gain a non-invasive assessment of tumor hypoxia within the whole tumor, with 18F-fluoromisonidazole (18F-FMISO) and 18F-flouroazomycin arabinoside (18F-FAZA) being the most promising radiotracers. In this short review, we aim to discuss the available clinical studies focused on the use of 18F-FAZA PET/computed tomography in patients affected by high-grade glioma.

KW - 18F-FAZA

KW - brain tumor

KW - glioma

KW - hypoxia

KW - PET/CT

KW - PET/MRI

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SN - 0393-6155

VL - 35

SP - 42

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JO - International Journal of Biological Markers

JF - International Journal of Biological Markers

IS - 1_suppl

ER -

18F-FAZA PET imaging in tumor hypoxia: A focus on high-grade glioma

Abstract

Keywords

ASJC Scopus subject areas

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