18F-FAZA PET imaging in tumor hypoxia: A focus on high-grade glioma

Paola Mapelli, Maria Picchio

Research output: Contribution to journalArticlepeer-review


The presence of hypoxia is a typical feature of solid tumors and has been identified in many neoplasms, favouring the survival of malignant cells in a hostile environment and the expression of an aggressive phenotype. Malignant brain tumors have large proportions of hypoxic tissue, thus contributing to resistance to radiation and chemotherapy. Positron emission tomography (PET) is an attractive technique to gain a non-invasive assessment of tumor hypoxia within the whole tumor, with 18F-fluoromisonidazole (18F-FMISO) and 18F-flouroazomycin arabinoside (18F-FAZA) being the most promising radiotracers. In this short review, we aim to discuss the available clinical studies focused on the use of 18F-FAZA PET/computed tomography in patients affected by high-grade glioma.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalInternational Journal of Biological Markers
Issue number1_suppl
Publication statusPublished - 2020


  • 18F-FAZA
  • brain tumor
  • glioma
  • hypoxia
  • PET/CT

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Clinical Biochemistry
  • Cancer Research


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