Stella Gagliardi

Research output

Research output per year 2010 2018 2021 2022 2022

• 85 Article
• 8 Review article
• 1 Letter

Research output per year

Research output per year

Search results

• 2022

  Bisdemethoxycurcumin (BDC)-Loaded H-Ferritin-Nanocages Mediate the Regulation of Inflammation in Alzheimer's Disease Patients

  Gagliardi, S., Truffi, M., Tinelli, V., Garofalo, M., Pandini, C., Cotta Ramusino, M., Perini, G., Costa, A., Negri, S., Mazzucchelli, S., Bonizzi, A., Sitia, L., Busacca, M., Sevieri, M., Mocchi, M., Ricciardi, A., Prosperi, D., Corsi, F., Cereda, C. & Morasso, C., Aug 17 2022, In: International journal of molecular sciences. 23, 16, 9237.

  Research output: Contribution to journal › Article › peer-review

  • bis(4-hydroxycinnamoyl)methane 100%
  • Apoferritins 83%
  • Alzheimer Disease 44%
  • Inflammation 33%
  • Solubility 9%

• Bisdemethoxycurcumin (BDC)-Loaded H-Ferritin-Nanocages Mediate the Regulation of Inflammation in Alzheimer’s Disease Patients

  Gagliardi, S., Truffi, M., Tinelli, V., Garofalo, M., Pandini, C., Cotta Ramusino, M., Perini, G., Costa, A., Negri, S., Mazzucchelli, S., Bonizzi, A., Sitia, L., Busacca, M., Sevieri, M., Mocchi, M., Ricciardi, A., Prosperi, D., Corsi, F., Cereda, C. & Morasso, C., 2022, In: International Journal of Molecular Sciences. 23, 16

  Research output: Contribution to journal › Article › peer-review

• Characterization of Mitochondrial Alterations in Aicardi-Goutières Patients Mutated in RNASEH2A and RNASEH2B Genes

  Dragoni, F., Garau, J., Sproviero, D., Orcesi, S., Varesio, C., De Siervi, S., Gagliardi, S., Cereda, C. & Pansarasa, O., Nov 21 2022, In: International journal of molecular sciences. 23, 22

  Research output: Contribution to journal › Article › peer-review

  • Aicardi Syndrome 100%
  • Mitochondrial DNA 90%
  • Cell Line 59%
  • Genes 40%
  • Mitochondria 23%

• Comparison of Two RNA Extraction Methods for the Molecular Detection of SARS-CoV-2 from Nasopharyngeal Swab Samples

  Scarabotto, A., Balestro, S., Gagliardi, S. & Trotti, R., Jun 27 2022, In: Diagn.. 12, 7

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus 100%
  • RNA 47%
  • RNA Viruses 38%
  • Reverse Transcriptase Polymerase Chain Reaction 34%
  • Nucleic Acids 33%

• COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and Microthrombosis

  Poloni, T. E., Moretti, M., Medici, V., Turturici, E., Belli, G., Cavriani, E., Visonà, S. D., Rossi, M., Fantini, V., Ferrari, R. R., Carlos, A. F., Gagliardi, S., Tronconi, L., Guaita, A. & Ceroni, M., Oct 4 2022, In: Cells. 11, 19, p. 3124

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus 100%
  • Macrophages 79%
  • Heart 73%
  • Pathology 71%
  • T-Lymphocytes 69%

• Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer's Disease and Lewy Body Dementia

  Palmieri, I., Poloni, T. E., Medici, V., Zucca, S., Davin, A., Pansarasa, O., Ceroni, M., Tronconi, L., Guaita, A., Gagliardi, S. & Cereda, C., Jul 13 2022, In: Biomedicines. 10, 7

  Research output: Contribution to journal › Article › peer-review

  • Lewy Body Disease 100%
  • Neuropathology 88%
  • Alzheimer Disease 61%
  • RNA Sequence Analysis 22%
  • High-Throughput Nucleotide Sequencing 18%

• Extracellular Vesicles Derived From Plasma of Patients With Neurodegenerative Disease Have Common Transcriptomic Profiling

  Sproviero, D., Gagliardi, S., Zucca, S., Arigoni, M., Giannini, M., Garofalo, M., Fantini, V., Pansarasa, O., Avenali, M., Ramusino, M. C., Diamanti, L., Minafra, B., Perini, G., Zangaglia, R., Costa, A., Ceroni, M., Calogero, R. A. & Cereda, C., 2022, In: Frontiers in Aging Neuroscience. 14, p. 785741

  Research output: Contribution to journal › Article › peer-review

  • Extracellular Vesicles 100%
  • Neurodegenerative Diseases 73%
  • Messenger RNA 48%
  • Frontotemporal Dementia With Motor Neuron Disease 37%
  • RNA 33%

• Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients

  Bordoni, M., Pansarasa, O., Scarian, E., Cristofani, R., Leone, R., Fantini, V., Garofalo, M., Diamanti, L., Bernuzzi, S., Gagliardi, S., Carelli, S., Poletti, A. & Cereda, C., Apr 1 2022, In: Cells. 11, 8, 1272.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitophagy 100%
  • Lysosomes 74%
  • Blood Cells 60%
  • Mitochondria 43%
  • Trehalose 43%

• Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients

  Bordoni, M., Pansarasa, O., Scarian, E., Cristofani, R., Leone, R., Fantini, V., Garofalo, M., Diamanti, L., Bernuzzi, S., Gagliardi, S., Carelli, S., Poletti, A. & Cereda, C., Apr 9 2022, In: Cells. 11, 8, p. 1272

  Research output: Contribution to journal › Article › peer-review

  • Mitophagy 100%
  • Lysosomes 74%
  • Blood Cells 60%
  • Mitochondria 43%
  • Trehalose 43%

• Neurodegenerative Disease-Associated TDP-43 Fragments Are Extracellularly Secreted with CASA Complex Proteins

  Casarotto, E., Sproviero, D., Corridori, E., Gagliani, M. C., Cozzi, M., Chierichetti, M., Cristofani, R., Ferrari, V., Galbiati, M., Mina, F., Piccolella, M., Rusmini, P., Tedesco, B., Gagliardi, S., Cortese, K., Cereda, C., Poletti, A. & Crippa, V., Feb 2 2022, In: Cells. 11, 3

  Research output: Contribution to journal › Article › peer-review

  • Macroautophagy 100%
  • Extracellular Vesicles 84%
  • Neurodegenerative Diseases 62%
  • Quality Control 34%
  • Proteins 26%

• RNA Molecular Signature Profiling in PBMCs of Sporadic ALS Patients: HSP70 Overexpression Is Associated with Nuclear SOD1

  Garofalo, M., Pandini, C., Bordoni, M., Jacchetti, E., Diamanti, L., Carelli, S., Raimondi, M. T., Sproviero, D., Crippa, V., Carra, S., Poletti, A., Pansarasa, O., Gagliardi, S. & Cereda, C., Jan 15 2022, In: Cells. 11, 2

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic lateral sclerosis 1 100%
  • Superoxide Dismutase-1 94%
  • Blood Cells 61%
  • RNA 51%
  • Amyotrophic Lateral Sclerosis 32%

• The worldwide spread of Aedes albopictus: New insights from mitogenomes

  Battaglia, V., Agostini, V., Moroni, E., Colombo, G., Lombardo, G., Rambaldi Migliore, N., Gabrieli, P., Garofalo, M., Gagliardi, S., Gomulski, L. M., Ferretti, L., Semino, O., Malacrida, A. R., Gasperi, G., Achilli, A., Torroni, A. & Olivieri, A., 2022, In: Frontiers in Genetics. 13, p. 931163

  Research output: Contribution to journal › Article › peer-review

  • Aedes 100%
  • Culicidae 85%
  • Mitochondrial DNA 56%
  • Introduced Species 42%
  • Arboviruses 36%
• 2021

  Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis

  Johnson, J. O., Chia, R., Miller, D. E., Li, R., Kumaran, R., Abramzon, Y., Alahmady, N., Renton, A. E., Topp, S. D., Gibbs, J. R., Cookson, M. R., Sabir, M. S., Dalgard, C. L., Troakes, C., Jones, A. R., Shatunov, A., Iacoangeli, A., Al Khleifat, A., Ticozzi, N., Silani, V., & 249 othersGellera, C., Blair, I. P., Dobson-Stone, C., Kwok, J. B., Bonkowski, E. S., Palvadeau, R., Tienari, P. J., Morrison, K. E., Shaw, P. J., Al-Chalabi, A., Brown R.H., J., Calvo, A., Mora, G., Al-Saif, H., Gotkine, M., Leigh, F., Chang, I. J., Perlman, S. J., Glass, I., Scott, A. I., Shaw, C. E., Basak, A. N., Landers, J. E., Chiò, A., Crawford, T. O., Smith, B. N., Traynor, B. J., Fallini, C., Gkazi, A. S., Scotter, E. L., Kenna, K. P., Keagle, P., Tiloca, C., Vance, C., Colombrita, C., King, A., Pensato, V., Castellotti, B., Baas, F., Ten Asbroek, A. L. M. A., McKenna-Yasek, D., McLaughlin, R. L., Polak, M., Asress, S., Esteban-Pérez, J., Stevic, Z., D'Alfonso, S., Mazzini, L., Comi, G. P., Del Bo, R., Ceroni, M., Gagliardi, S., Querin, G., Bertolin, C., Van Rheenen, W., Rademakers, R., Van Blitterswijk, M., Lauria, G., Duga, S., Corti, S., Cereda, C., Corrado, L., Sorarù, G., Williams, K. L., Nicholson, G. A., Leblond-Manry, C., Rouleau, G. A., Hardiman, O., Veldink, J. H., Van Den Berg, L. H., Pall, H., Turner, M. R., Talbot, K., Taroni, F., García-Redondo, A., Wu, Z., Glass, J. D., Ratti, A., Adeleye, A., Soltis, A. R., Alba, C., Viollet, C., Bacikova, D., Hupalo, D. N., Sukumar, G., Pollard, H. B., Wilkerson, M. D., Martinez, E. M., Ahmed, S., Arepalli, S., Baloh, R. H., Bowser, R., Brady, C. B., Brice, A., Broach, J., Campbell, R. H., Camu, W., Cooper-Knock, J., Ding, J., Drepper, C., Drory, V. E., Dunckley, T. L., Eicher, J. D., England, B. K., Faghri, F., Feldman, E., Floeter, M. K., Fratta, P., Geiger, J. T., Gerhard, G., Gibson, S. B., Hardy, J., Harms, M. B., Heiman-Patterson, T. D., Hernandez, D. G., Jansson, L., Kirby, J., Kowall, N. W., Laaksovirta, H., Landeck, N., Landi, F., Le Ber, I., Lumbroso, S., Macgowan, D. J. L., Maragakis, N. J., Mouzat, K., Murphy, N. A., Myllykangas, L., Nalls, M. A., Orrell, R. W., Ostrow, L. W., Pamphlett, R., Pickering-Brown, S., Pioro, E. P., Pletnikova, O., Pliner, H. A., Pulst, S. M., Ravits, J. M., Rivera, A., Robberecht, W., Rogaeva, E., Rollinson, S., Rothstein, J. D., Scholz, S. W., Sendtner, M., Sidle, K. C., Simmons, Z., Singleton, A. B., Smith, N., Stone, D. J., Troncoso, J. C., Valori, M., Van Damme, P., Van Deerlin, V. M., Van Den Bosch, L., Zinman, L., Angelocola, S. M., Ausiello, F. P., Barberis, M., Bartolomei, I., Battistini, S., Bersano, E., Bisogni, G., Borghero, G., Brunetti, M., Cabona, C., Canale, F., Canosa, A., Cantisani, T. A., Capasso, M., Caponnetto, C., Cardinali, P., Carrera, P., Casale, F., Colletti, T., Conforti, F. L., Conte, A., Conti, E., Corbo, M., Cuccu, S., Dalla Bella, E., D'Errico, E., Demarco, G., Dubbioso, R., Ferrarese, C., Ferraro, P. M., Filippi, M., Fini, N., Floris, G., Fuda, G., Gallone, S., Gianferrari, G., Giannini, F., Grassano, M., Greco, L., Iazzolino, B., Introna, A., La Bella, V., Lattante, S., Liguori, R., Logroscino, G., Logullo, F. O., Lunetta, C., Mandich, P., Mandrioli, J., Manera, U., Manganelli, F., Marangi, G., Marinou, K., Marrosu, M. G., Martinelli, I., Messina, S., Moglia, C., Mosca, L., Murru, M. R., Origone, P., Passaniti, C., Petrelli, C., Petrucci, A., Pozzi, S., Pugliatti, M., Quattrini, A., Ricci, C., Riolo, G., Riva, N., Russo, M., Sabatelli, M., Salamone, P., Salivetto, M., Salvi, F., Santarelli, M., Sbaiz, L., Sideri, R., Simone, I., Simonini, C., Spataro, R., Tanel, R., Tedeschi, G., Ticca, A., Torriello, A., Tranquilli, S., Tremolizzo, L., Trojsi, F., Vasta, R., Vacchiano, V., Vita, G., Volanti, P., Zollino, M. & Zucchi, E., 2021, In: JAMA Neurology. 78, 10, p. 1236-1248 13 p.

  Research output: Contribution to journal › Article › peer-review

• Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis

  Johnson, J. O., Ticozzi, N., Silani, V., Gellera, C., Mora, G., Ticozzi, N., Tiloca, C., Colombrita, C., Pensato, V., Castellotti, B., Comi, G. P., Del Bo, R., Ceroni, M., Gagliardi, S., Lauria, G., Duga, S., Corti, S., Cereda, C., Taroni, F., Gellera, C., & 30 othersRatti, A., Silani, V., Landi, F., Mora, G., Bartolomei, I., Bersano, E., Cabona, C., Caponnetto, C., Carrera, P., Dalla Bella, E., Filippi, M., Lattante, S., Lauria, G., Liguori, R., Mandich, P., Martinelli, I., Messina, S., Mora, G., Origone, P., Quattrini, A., Ricci, C., Riva, N., Russo, M., Sabatelli, M., Salvi, F., Sideri, R., Spataro, R., Vacchiano, V., Volanti, P. & Zollino, M., 2021, (Accepted/In press) In: JAMA Neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • Genes 37%
  • Whole Exome Sequencing 23%
  • Hereditary Sensory and Autonomic Neuropathies 10%
  • Failure to Thrive 8%

• Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis

  Johnson, J. O., Chia, R., Miller, D. E., Ticozzi, N., Silani, V., Gellera, C., Mora, G., Ticozzi, N., Tiloca, C., Colombrita, C., Pensato, V., Castellotti, B., Comi, G. P., Del Bo, R., Ceroni, M., Gagliardi, S., Lauria, G., Duga, S., Corti, S., Cereda, C., & 30 othersTaroni, F., Gellera, C., Ratti, A., Silani, V., Landi, F., Mora, G., Bartolomei, I., Bersano, E., Cabona, C., Caponnetto, C., Carrera, P., Dalla Bella, E., Filippi, M., Lattante, S., Lauria, G., Liguori, R., Mandich, P., Martinelli, I., Mora, G., Origone, P., Quattrini, A., Ricci, C., Riva, N., Sabatelli, M., Salvi, F., Sideri, R., Spataro, R., Vacchiano, V., Volanti, P. & Zollino, M., Aug 30 2021, (E-pub ahead of print) In: JAMA Neurology. 78 , 10, p. 1236-48 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Genes 37%
  • Whole Exome Sequencing 23%
  • Hereditary Sensory and Autonomic Neuropathies 10%
  • Failure to Thrive 8%

• Case Report: Novel Compound Heterozygous RNASEH2B Mutations Cause Aicardi-Goutières Syndrome

  Garau, J., Masnada, S., Dragoni, F., Sproviero, D., Fogolari, F., Gagliardi, S., Izzo, G., Varesio, C., Orcesi, S., Veggiotti, P., Zuccotti, G. V., Pansarasa, O., Tonduti, D. & Cereda, C., 2021, In: Front. Immunol.. 12, p. 672952

  Research output: Contribution to journal › Article › peer-review

  • Aicardi Syndrome 100%
  • Ribonucleases 64%
  • Mutation 32%
  • High-Throughput Nucleotide Sequencing 11%
  • Nervous System Diseases 10%

• COVID-19 patients and Dementia: Frontal cortex transcriptomic data

  Garofalo, M., Gagliardi, S., Zucca, S., Pandini, C., Dragoni, F., Sproviero, D., Pansarasa, O., Poloni, T. E., Medici, V., Davin, A., Visonà, S. D., Moretti, M., Guaita, A., Ceroni, M., Tronconi, L. & Cereda, C., Oct 2021, In: Data in Brief. 38, p. 107432

  Research output: Contribution to journal › Article › peer-review

  • Frontal Lobe 100%
  • Dementia 89%
  • Genes 42%
  • SARS Virus 39%
  • Whole Exome Sequencing 31%

• COVID-19-related neuropathology and microglial activation in elderly with and without dementia

  Poloni, T. E., Medici, V., Moretti, M., Visonà, S. D., Cirrincione, A., Carlos, A. F., Davin, A., Gagliardi, S., Pansarasa, O., Cereda, C., Tronconi, L., Guaita, A. & Ceroni, M., Sept 2021, In: Brain Pathology. 31, 5, p. e12997

  Research output: Contribution to journal › Article › peer-review

  • Coronavirus 100%
  • Neuropathology 89%
  • SARS Virus 70%
  • Dementia 66%
  • Elderly 53%

• CovidArray: A Microarray-Based Assay with High Sensitivity for the Detection of Sars-Cov-2 in Nasopharyngeal Swabs

  Damin, F., Galbiati, S., Gagliardi, S., Cereda, C., Dragoni, F., Fenizia, C., Savasi, V., Sola, L. & Chiari, M., Apr 3 2021, In: Sensors. 21, 7, 2490.

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus 100%
  • Reverse Transcription 99%
  • Coronavirus 56%
  • Polymerase Chain Reaction 53%
  • Viral RNA 49%

• Covidarray: A microarray-based assay with high sensitivity for the detection of sars-cov-2 in nasopharyngeal swabs: Sensors (Basel)

  Damin, F., Galbiati, S., Gagliardi, S., Cereda, C., Dragoni, F., Fenizia, C., Savasi, V., Sola, L. & Chiari, M., 2021, In: Sensors. 21, 7, 2490.

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus 100%
  • Reverse Transcription 99%
  • Coronavirus 56%
  • Polymerase Chain Reaction 53%
  • Viral RNA 49%

• Detection of SARS-CoV-2 genome and whole transcriptome sequencing in Frontal Cortex of COVID-19 patients

  Gagliardi, S., Emanuele Poloni, T., Pandini, C., Garofalo, M., Dragoni, F., Medici, V., Davin, A., Damiana Visonà, S., Moretti, M., Sproviero, D., Pansarasa, O., Guaita, A., Ceroni, M., Tronconi, L. & Cereda, C., May 19 2021, In: Brain, Behavior, and Immunity. 97, 1, p. 3-21 18 p.

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus 100%
  • Whole Exome Sequencing 80%
  • Frontal Lobe 63%
  • Genome 46%
  • Hypoxia 40%

• Different mirna profiles in plasma derived small and large extracellular vesicles from patients with neurodegenerative diseases

  Sproviero, D., Gagliardi, S., Zucca, S., Arigoni, M., Giannini, M., Garofalo, M., Olivero, M., Dell’orco, M., Pansarasa, O., Bernuzzi, S., Avenali, M., Ramusino, M. C., Diamanti, L., Minafra, B., Perini, G., Zangaglia, R., Costa, A., Ceroni, M., Perrone‐bizzozero, N. I., Calogero, R. A., & 1 othersCereda, C., Mar 1 2021, In: International Journal of Molecular Sciences. 22, 5, p. 1-17 17 p., 2737.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neurodegenerative diseases 100%
  • MicroRNA 82%
  • Extracellular Vesicles 79%
  • Biomarkers 62%
  • Plasmas 61%

• Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases

  Sproviero, D., Gagliardi, S., Zucca, S., Arigoni, M., Giannini, M., Garofalo, M., Olivero, M., Dell'Orco, M., Pansarasa, O., Bernuzzi, S., Avenali, M., Cotta Ramusino, M., Diamanti, L., Minafra, B., Perini, G., Zangaglia, R., Costa, A., Ceroni, M., Perrone-Bizzozero, N. I., Calogero, R. A., & 1 othersCereda, C., Mar 8 2021, In: Int J Mol Sci. 22, 5, 2737.

  Research output: Contribution to journal › Article › peer-review

  • Extracellular Vesicles 100%
  • Neurodegenerative Diseases 73%
  • MicroRNAs 71%
  • Biomarkers 23%
  • RNA 16%

• Familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2

  Antonaci, F., Ravaglia, S., Grieco, G. S., Gagliardi, S., Cereda, C. & Costa, A., Mar 12 2021, In: The journal of headache and pain. 22, 1, p. 12

  Research output: Contribution to journal › Article › peer-review

  • Familial type 2 Hemiplegic migraine 100%
  • Missense Mutation 52%
  • Phenotype 30%
  • Genetic Association Studies 21%
  • Epilepsy 17%

• Homocysteine, Folic Acid, Cyanocobalamin, and Frailty in Older People: Findings From the "Invece. Ab" Study

  Guaita, A., Brunelli, L., Davin, A., Poloni, T. E., Vaccaro, R., Gagliardi, S., Pansarasa, O. & Cereda, C., 2021, In: Frontiers in Physiology. 12, p. 775803

  Research output: Contribution to journal › Article › peer-review

  • Frailty 100%
  • Vitamin B 12 96%
  • Homocysteine 94%
  • Folic Acid 86%
  • Sex Education 18%

• MINCR: A long non-coding RNA shared between cancer and neurodegeneration

  Pandini, C., Garofalo, M., Rey, F., Garau, J., Zucca, S., Sproviero, D., Bordoni, M., Berzero, G., Davin, A., Poloni, T. E., Pansarasa, O., Carelli, S., Gagliardi, S. & Cereda, C., Oct 15 2021, In: Genomics. 113, 6, p. 4039-4051 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Long Noncoding RNA 100%
  • Down-Regulation 43%
  • RNA Sequence Analysis 34%
  • Neoplasm Genes 33%
  • Amyotrophic Lateral Sclerosis 33%

• Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

  The American Genome Center (TAGC), The FALS Sequencing Consortium, The Genomics England Research Consortium, The International ALS/FTD Genomics Consortium (iAFGC), The International FTD Genetics Consortium (IFGC), The International LBD Genomics Consortium (iLBDGC), The NYGC ALS Consortium, the University of Maryland Brain and Tissue Bank and NIH NeuroBioBank & The PROSPECT Consortium, Feb 3 2021, In: Neuron. 109, 3, p. 448-460.e4

  Research output: Contribution to journal › Article › peer-review

  • Frontotemporal Dementia With Motor Neuron Disease 100%
  • Lewy Body Disease 23%
  • Huntington Disease 10%
  • Genetic Testing 9%
  • Ubiquitin 9%

• Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

  Dewan, R., Chia, R., Ding, J., Hickman, R. A., Stein, T. D., Abramzon, Y., Ahmed, S., Sabir, M. S., Portley, M. K., Tucci, A., Ibáñez, K., Shankaracharya, F. N. U., Keagle, P., Rossi, G., Caroppo, P., Tagliavini, F., Waldo, M. L., Johansson, P. M., Nilsson, C. F., Adeleye, A., & 434 othersAlba, C., Bacikova, D., Hupalo, D., Martinez, E. M., Pollard, H. B., Sukumar, G., Soltis, A. R., Tuck, M., Zhang, X., Wilkerson, M. D., Smith, B. N., Ticozzi, N., Fallini, C., Gkazi, A. S., Topp, S. D., Kost, J., Scotter, E. L., Kenna, K. P., Miller, J. W., Tiloca, C., Vance, C., Danielson, E. W., Troakes, C., Colombrita, C., Al-Sarraj, S., Lewis, E. A., King, A., Calini, D., Pensato, V., Castellotti, B., de Belleroche, J., Baas, F., ten Asbroek, A. L. M. A., Sapp, P. C., McKenna-Yasek, D., McLaughlin, R. L., Polak, M., Asress, S., Esteban-Pérez, J., Muñoz-Blanco, J. L., Stevic, Z., D'Alfonso, S., Mazzini, L., Comi, G. P., Del Bo, R., Ceroni, M., Gagliardi, S., Querin, G., Bertolin, C., van Rheenen, W., Diekstra, F. P., Rademakers, R., van Blitterswijk, M., Boylan, K. B., Lauria, G., Duga, S., Corti, S., Cereda, C., Corrado, L., Sorarù, G., Williams, K. L., Nicholson, G. A., Blair, I. P., Leblond-Manry, C., Rouleau, G. A., Hardiman, O., Morrison, K. E., Veldink, J. H., van den Berg, L. H., Al-Chalabi, A., Pall, H., Shaw, P. J., Turner, M. R., Talbot, K., Taroni, F., García-Redondo, A., Wu, Z., Gellera, C., Ratti, A., Brown R.H., J., Shaw, C. E., Ambrose, J. C., Arumugam, P., Baple, E. L., Bleda, M., Boardman-Pretty, F., Boissiere, J. M., Boustred, C. R., Brittain, H., Caulfield, M. J., Chan, G. C., Craig, C. E. H., Daugherty, L. C., de Burca, A., Devereau, A., Elgar, G., Foulger, R. E., Fowler, T., Furió-Tarí, P., Hackett, J. M., Halai, D., Hamblin, A., Henderson, S., Holman, J. E., Hubbard, T. J. P., Jackson, R., Jones, L. J., Kasperaviciute, D., Kayikci, M., Lahnstein, L., Lawson, K., Leigh, S. E. A., Leong, I. U. S., Lopez, J. F., Maleady-Crowe, F., Mason, J., McDonagh, E. M., Moutsianas, L., Mueller, M., Murugaesu, N., Need, A. C., Odhams, C. A., Patch, C., Perez-Gil, D., Polychronopoulos, D., Pullinger, J., Rahim, T., Rendon, A., Riesgo-Ferreiro, P., Rogers, T., Savage, K., Sawant, K., Scott, R. H., Siddiq, A., Sieghart, A., Smedley, D., Smith, K. R., Sosinsky, A., Spooner, W., Stevens, H. E., Stuckey, A., Sultana, R., Thomas, E. R. A., Thompson, S. R., Tregidgo, C., Walsh, E., Watters, S. A., Welland, M. J., Williams, E., Witkowska, K., Wood, S. M., Zarowiecki, M., Arepalli, S., Auluck, P., Baloh, R. H., Bowser, R., Brice, A., Broach, J., Camu, W., Chiò, A., Cooper-Knock, J., Corcia, P., Drepper, C., Drory, V. E., Dunckley, T. L., Faghri, F., Farren, J., Feldman, E., Floeter, M. K., Fratta, P., Gerhard, G., Gibson, S. B., Goutman, S. A., Heiman-Patterson, T. D., Hernandez, D. G., Hoover, B., Jansson, L., Kamel, F., Kirby, J., Kowall, N. W., Laaksovirta, H., Landi, F., Le Ber, I., Lumbroso, S., MacGowan, D. J., Maragakis, N. J., Mora, G., Mouzat, K., Myllykangas, L., Nalls, M. A., Orrell, R. W., Ostrow, L. W., Pamphlett, R., Pioro, E., Pulst, S. M., Ravits, J., Renton, A. E., Robberecht, W., Robey, I., Rogaeva, E., Rothstein, J. D., Sendtner, M., Sidle, K. C., Simmons, Z., Stone, D. J., Tienari, P. J., Trojanowski, J. Q., Troncoso, J. C., Valori, M., Van Damme, P., Van Den Bosch, L., Zinman, L., Albani, D., Borroni, B., Padovani, A., Bruni, A., Clarimon, J., Dols-Icardo, O., Illán-Gala, I., Lleó, A., Danek, A., Galimberti, D., Scarpini, E., Serpente, M., Graff, C., Chiang, H-H., Khoshnood, B., Öijerstedt, L., Morris, C. M., Nacmias, B., Sorbi, S., Nielsen, J. E., Hjermind, L. E., Novelli, V., Puca, A. A., Pastor, P., Alvarez, I., Diez-Fairen, M., Aguilar, M., Perneczky, R., Diehl-Schimd, J., Rossi, M., Ruiz, A., Boada, M., Hernández, I., Moreno-Grau, S., Schlachetzki, J. C., Aarsland, D., Albert, M. S., Attems, J., Barrett, M. J., Beach, T. G., Bekris, L. M., Bennett, D. A., Besser, L. M., Bigio, E. H., Black, S. E., Boeve, B. F., Bohannan, R. C., Brett, F., Brunetti, M., Caraway, C. A., Palma, J-A., Calvo, A., Canosa, A., Dickson, D., Duyckaerts, C., Faber, K., Ferman, T., Flanagan, M. E., Floris, G., Foroud, T. M., Fortea, J., Gan-Or, Z., Gentleman, S., Ghetti, B., Gibbs, J. R., Goate, A., Goldstein, D., González-Aramburu, I., Graff-Radford, N. R., Hodges, A. K., Hu, H-C., Hupalo, D., Infante, J., Iranzo, A., Kaiser, S. M., Kaufmann, H., Keith, J., Kim, R. C., Klein, G., Krüger, R., Kukull, W., Kuzma, A., Lage, C., Lesage, S., Leverenz, J. B., Logroscino, G., Lopez, G., Love, S., Mao, Q., Marti, M. J., Martinez-McGrath, E., Masellis, M., Masliah, E., May, P., McKeith, I., Mesulam, M-M., Monuki, E. S., Newell, K. L., Norcliffe-Kaufmann, L., Palmer, L., Perkins, M., Pletnikova, O., Molina-Porcel, L., Reynolds, R. H., Rodríguez-Rodríguez, E., Rohrer, J. D., Sanchez-Juan, P., Scherzer, C. R., Serrano, G. E., Shakkottai, V., Sidransky, E., Tayebi, N., Thomas, A. J., Tilley, B. S., Walton, R. L., Woltjer, R., Wszolek, Z. K., Xiromerisiou, G., Zecca, C., Phatnani, H., Kwan, J., Sareen, D., Broach, J. R., Arcila-Londono, X., Lee, E. B., Shneider, N. A., Fraenkel, E., Zaitlen, N., Berry, J. D., Malaspina, A., Cox, G. A., Thompson, L. M., Finkbeiner, S., Dardiotis, E., Miller, T. M., Chandran, S., Pal, S., Hornstein, E., Heiman-Patterson, T., Hammell, M. G., Patsopoulos, N. A., Butovsky, O., Dubnau, J., Nath, A., Harms, M., Aronica, E., Poss, M., Phillips-Cremins, J., Crary, J., Atassi, N., Lange, D. J., Adams, D. J., Stefanis, L., Gotkine, M., Babu, S., Raj, T., Paganoni, S., Shalem, O., Smith, C., Zhang, B., Harris, B., Broce, I., Ravits, J., McMillan, C., Menon, V., Wu, L., Altschuler, S., Amar, K., Archibald, N., Bandmann, O., Capps, E., Church, A., Coebergh, J., Costantini, A., Critchley, P., Ghosh, B. C., Hu, M. T. M., Kobylecki, C., Leigh, P. N., Mann, C., Massey, L. A., Morris, H. R., Nath, U., Pavese, N., Paviour, D., Sharma, J., Vaughan, J., Rowe, J. B., Benussi, L., Binetti, G., Ghidoni, R., Jabbari, E., Viollet, C., Glass, J. D., Singleton, A. B., Silani, V., Ross, O. A., Ryten, M., Torkamani, A., Tanaka, T., Ferrucci, L., Resnick, S. M., Pickering-Brown, S., Brady, C. B., Kowal, N., Hardy, J. A., Van Deerlin, V., Vonsattel, J. P., Harms, M. B., Ferrari, R., Landers, J. E., Dalgard, C. L., Scholz, S. W., Traynor, B. J., Consortium, T. PROSPECT., (TAGC), T. A. G. C., Consortium, T. FALS. S., Consortium, T. G. E. R., (iAFGC), T. I. ALSFTD. G. C., (IFGC), T. I. FTD. G. C., The International LBD Genomics Consortium (iLBDGC), T. NYGC. ALS. C. & NeuroBioBank, T. U. O. M. B. A. T. B. A. NIH., 2021, In: Neuron. 109, 3, p. 448

  Research output: Contribution to journal › Article › peer-review

• PSEN1 Compound Heterozygous Mutations Associated with Cerebral Amyloid Angiopathy and Cognitive Decline Phenotype

  Palmieri, I., Valente, M., Farina, L. M., Gana, S., Minafra, B., Zangaglia, R., Pansarasa, O., Sproviero, D., Costa, A., Pacchetti, C., Pichiecchio, A., Gagliardi, S. & Cereda, C., Apr 8 2021, In: Int J Mol Sci. 22, 8

  Research output: Contribution to journal › Article › peer-review

  • Cerebral Amyloid Angiopathy 100%
  • Presenilin-1 98%
  • Cognitive Dysfunction 58%
  • Phenotype 42%
  • Mutation 39%

• Weaving mitochondrial dna and y-chromosome variation in the panamanian genetic canvas

  Migliore, N. R., Colombo, G., Capodiferro, M. R., Mazzocchi, L., Chero Osorio, A. M., Raveane, A., Tribaldos, M., Perego, U. A., Mendizábal, T., García Montón, A., Lombardo, G., Grugni, V., Garofalo, M., Ferretti, L., Cereda, C., Gagliardi, S., Cooke, R., Smith-Guzmán, N., Olivieri, A., Aram, B., & 4 othersTorroni, A., Motta, J., Semino, O. & Achilli, A., Dec 2021, In: Genes. 12, 12, 1921.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Y Chromosome 100%
  • Panama 82%
  • Chromosomes 65%
  • Mitochondrial DNA 57%
  • Enslaved Persons 45%

• Weaving Mitochondrial DNA and Y-Chromosome Variation in the Panamanian Genetic Canvas

  Rambaldi Migliore, N., Colombo, G., Capodiferro, M. R., Mazzocchi, L., Chero Osorio, A. M., Raveane, A., Tribaldos, M., Perego, U. A., Mendizábal, T., Montón, A. G., Lombardo, G., Grugni, V., Garofalo, M., Ferretti, L., Cereda, C., Gagliardi, S., Cooke, R., Smith-Guzmán, N., Olivieri, A., Aram, B., & 4 othersTorroni, A., Motta, J., Semino, O. & Achilli, A., Nov 29 2021, In: Genes. 12, 12

  Research output: Contribution to journal › Article › peer-review

  • Y Chromosome 100%
  • Mitochondrial DNA 86%
  • Panama 82%
  • Enslaved Persons 45%
  • Gene Pool 41%

• α-Synuclein antisense transcript SNCA-AS1 regulates synapses- and aging-related genes suggesting its implication in Parkinson's disease

  Rey, F., Pandini, C., Messa, L., Launi, R., Barzaghini, B., Zangaglia, R., Raimondi, M. T., Gagliardi, S., Cereda, C., Zuccotti, G. V. & Carelli, S., Nov 19 2021, (E-pub ahead of print) In: Aging Cell. p. e13504

  Research output: Contribution to journal › Article › peer-review

  • Synucleins 100%
  • Synapses 60%
  • Parkinson Disease 55%
  • Up-Regulation 28%
  • Genes 26%
• 2020

  Alzheimer's, Parkinson's Disease and Amyotrophic Lateral Sclerosis Gene Expression Patterns Divergence Reveals Different Grade of RNA Metabolism Involvement

  Garofalo, M., Pandini, C., Bordoni, M., Pansarasa, O., Rey, F., Costa, A., Minafra, B., Diamanti, L., Zucca, S., Carelli, S., Cereda, C. & Gagliardi, S., Dec 14 2020, In: International Journal of Molecular Sciences. 21, 24

  Research output: Contribution to journal › Article › peer-review

  • Parkinson disease 100%
  • gene expression 85%
  • Metabolism 80%
  • metabolism 78%
  • RNA 76%

• Curcumin Formulations and Trials: What's New in Neurological Diseases

  Gagliardi, S., Morasso, C., Stivaktakis, P., Pandini, C., Tinelli, V., Tsatsakis, A., Prosperi, D., Hickey, M., Corsi, F. & Cereda, C., 2020, In: Molecules (Basel, Switzerland). 25, 22, 5389.

  Research output: Contribution to journal › Article › peer-review

  • Curcumin 100%
  • bioavailability 69%
  • animal models 60%
  • formulations 60%
  • neurology 59%

• Dissecting the effect of a 3D microscaffold on the transcriptome of neural stem cells with computational approaches: A focus on mechanotransduction

  Rey, F., Pandini, C., Barzaghini, B., Messa, L., Giallongo, T., Pansarasa, O., Gagliardi, S., Brilli, M., Zuccotti, G. V., Cereda, C., Raimondi, M. T. & Carelli, S., Sept 2 2020, In: International Journal of Molecular Sciences. 21, 18, p. 1-37 37 p., 6775.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem cells 100%
  • stem cells 97%
  • Neural Stem Cells 79%
  • Regenerative Medicine 77%
  • Transcriptome 65%

• Maternal dietary exposure to low-dose bisphenol a affects metabolic and signaling pathways in the brain of rat fetuses

  Tonini, C., Segatto, M., Gagliardi, S., Bertoli, S., Leone, A., Barberio, L., Mandalà, M. & Pallottini, V., 2020, In: Nutrients. 12, 5

  Research output: Contribution to journal › Article › peer-review

• Raman spectroscopy reveals biochemical differences in plasma derived extracellular vesicles from sporadic amyotrophic lateral sclerosis patients

  Morasso, C. F., Sproviero, D., Mimmi, M. C., Giannini, M., Gagliardi, S., Vanna, R., Diamanti, L., Bernuzzi, S., Piccotti, F., Truffi, M., Pansarasa, O., Corsi, F. & Cereda, C., Jun 26 2020, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 29, p. 102249

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic lateral sclerosis 1 100%
  • Raman spectroscopy 99%
  • Raman Spectrum Analysis 98%
  • Extracellular Vesicles 88%
  • Plasmas 68%

• Raman spectroscopy reveals biochemical differences in plasma derived extracellular vesicles from sporadic Amyotrophic Lateral Sclerosis patients: Nanomedicine: Nanotechnology, Biology, and Medicine

  Morasso, C. F., Sproviero, D., Mimmi, M. C., Giannini, M., Gagliardi, S., Vanna, R., Diamanti, L., Bernuzzi, S., Piccotti, F., Truffi, M., Pansarasa, O., Corsi, F. & Cereda, C., Oct 2020, In: Nanomed. Nanotechnol. Biol. Med.. 29, 102249.

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic lateral sclerosis 1 100%
  • Raman Spectrum Analysis 98%
  • Nanomedicine 95%
  • Nanotechnology 89%
  • Extracellular Vesicles 88%

• Raman spectroscopy reveals biochemical differences in plasma derived extracellular vesicles from sporadic Amyotrophic Lateral Sclerosis patients

  Morasso, C. F., Sproviero, D., Mimmi, M. C., Giannini, M., Gagliardi, S., Vanna, R., Diamanti, L., Bernuzzi, S., Piccotti, F., Truffi, M., Pansarasa, O., Corsi, F. & Cereda, C., 2020, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 29, 102249.

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic lateral sclerosis 1 100%
  • Raman spectroscopy 99%
  • Raman Spectrum Analysis 98%
  • Extracellular Vesicles 88%
  • Plasmas 68%

• Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis

  Stoccoro, A., Smith, A. R., Mosca, L., Marocchi, A., Gerardi, F., Lunetta, C., Cereda, C., Gagliardi, S., Lunnon, K., Migliore, L. & Coppedè, F., Sept 11 2020, In: Clinical Epigenetics. 12, 1, p. 137

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic lateral sclerosis 1 100%
  • Methylation 67%
  • Amyotrophic Lateral Sclerosis 51%
  • Mitochondrial DNA 50%
  • Epigenomics 11%
• 2019

  Agenesis of the putamen and globus pallidus caused by recessive mutations in the homeobox gene GSX2

  De Mori, R., Severino, M., Mancardi, M. M., Anello, D., Tardivo, S., Biagini, T., Capra, V., Casella, A., Cereda, C., Copeland, B. R., Gagliardi, S., Gamucci, A., Ginevrino, M., Illi, B., Lorefice, E., Musaev, D., Stanley, V., Micalizzi, A., Gleeson, J. G., Mazza, T., & 2 othersRossi, A. & Valente, E. M., 2019, In: Brain. 142, 10, p. 2965-2978 14 p.

  Research output: Contribution to journal › Article › peer-review

• Agenesis of the putamen and globus pallidus caused by recessive mutations in the homeobox gene GSX2

  De Mori, R., Severino, M., Mancardi, M. M., Anello, D., Tardivo, S., Biagini, T., Capra, V., Casella, A., Cereda, C., Copeland, B. R., Gagliardi, S., Gamucci, A., Ginevrino, M., Illi, B., Lorefice, E., Musaev, D., Stanley, V., Micalizzi, A., Gleeson, J. G., Mazza, T., & 2 othersRossi, A. & Valente, E. M., 2019, In: Brain : a journal of neurology. 142, 10, p. 2965-2978 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Globus Pallidus 100%
  • Homeobox Genes 99%
  • Putamen 95%
  • Basal Ganglia 87%
  • Mutation 47%

• Agenesis of the putamen and globus pallidus caused by recessive mutations in the homeobox gene GSX2

  De Mori, R., Severino, M., Mancardi, M. M., Anello, D., Tardivo, S., Biagini, T., Capra, V., Casella, A., Cereda, C., Copeland, B. R., Gagliardi, S., Gamucci, A., Ginevrino, M., Illi, B., Lorefice, E., Musaev, D., Stanley, V., Micalizzi, A., Gleeson, J. G., Mazza, T., & 2 othersRossi, A. & Valente, E. M., 2019, In: Brain. 142, (10), p. 2965-78

  Research output: Contribution to journal › Article › peer-review

  • Globus Pallidus 100%
  • Homeobox Genes 99%
  • Putamen 95%
  • Basal Ganglia 87%
  • Mutation 47%

• Agenesis of the putamen and globus pallidus caused by recessive mutations in the homeobox gene GSX2

  De Mori, R., Severino, M., Mancardi, M. M., Anello, D., Tardivo, S., Biagini, T., Capra, V., Casella, A., Cereda, C., Copeland, B. R., Gagliardi, S., Gamucci, A., Ginevrino, M., Illi, B., Lorefice, E., Musaev, D., Stanley, V., Micalizzi, A., Gleeson, J. G., Mazza, T., & 2 othersRossi, A. & Valente, E. M., 2019, In: Brain. 142, 10, p. 2965-2978 14 p.

  Research output: Contribution to journal › Article › peer-review

• Agenesis of the putamen and globus pallidus caused by recessive mutations in the homeobox gene GSX2

  De Mori, R., Severino, M., Mancardi, M. M., Anello, D., Tardivo, S., Biagini, T., Capra, V., Casella, A., Cereda, C., Copeland, B. R., Gagliardi, S., Gamucci, A., Ginevrino, M., Illi, B., Lorefice, E., Musaev, D., Stanley, V., Micalizzi, A., Gleeson, J. G., Mazza, T., & 2 othersRossi, A. & Valente, E. M., 2019, In: Brain : a journal of neurology. 142 , (10), p. 2965-78 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Globus Pallidus 100%
  • Homeobox Genes 99%
  • Putamen 95%
  • Basal Ganglia 87%
  • Mutation 47%

• Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients

  Sproviero, D., La Salvia, S., Colombo, F., Zucca, S., Pansarasa, O., Diamanti, L., Costa, A., Lova, L., Giannini, M., Gagliardi, S., Lauranzano, E., Matteoli, M., Ceroni, M., Malaspina, A. & Cereda, C., 2019, In: Frontiers in Neuroscience. 13, p. 344

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Disease Progression 74%
  • Leukocytes 73%
  • Biomarkers 60%
  • Alzheimer Disease 20%

• Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients

  Sproviero, D., La Salvia, S., Colombo, F., Zucca, S., Pansarasa, O., Diamanti, L., Costa, A., Lova, L., Giannini, M., Gagliardi, S., Lauranzano, E., Matteoli, M., Ceroni, M., Malaspina, A. & Cereda, C., 2019, In: Frontiers in Neuroscience. 13

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Disease Progression 74%
  • Leukocytes 73%
  • Biomarkers 60%
  • Alzheimer Disease 20%

• Nuclear Phospho-SOD1 Protects DNA from Oxidative Stress Damage in Amyotrophic Lateral Sclerosis

  Bordoni, M., Pansarasa, O., Dell'Orco, M., Crippa, V., Gagliardi, S., Sproviero, D., Bernuzzi, S., Diamanti, L., Ceroni, M., Tedeschi, G., Poletti, A. & Cereda, C., May 22 2019, In: Journal of Clinical Medicine. 8, 5

  Research output: Contribution to journal › Article › peer-review

  • Superoxide Dismutase-1 100%
  • Amyotrophic Lateral Sclerosis 84%
  • Oxidative Stress 58%
  • DNA Damage 51%
  • DNA 44%

• Nuclear Phospho-SOD1 Protects DNA from Oxidative Stress Damage in Amyotrophic Lateral Sclerosis

  Bordoni, M., Pansarasa, O., Dell'Orco, M., Crippa, V., Gagliardi, S., Sproviero, D., Bernuzzi, S., Diamanti, L., Ceroni, M., Tedeschi, G., Poletti, A. & Cereda, C., May 22 2019, In: Journal of Clinical Medicine. 8, 5

  Research output: Contribution to journal › Article › peer-review

  • Superoxide Dismutase-1 100%
  • Amyotrophic Lateral Sclerosis 84%
  • Oxidative Stress 58%
  • DNA Damage 51%
  • DNA 44%

• RNA-Seq profiling in peripheral blood mononuclear cells of amyotrophic lateral sclerosis patients and controls

  Zucca, S., Gagliardi, S., Pandini, C., Diamanti, L., Bordoni, M., Sproviero, D., Arigoni, M., Olivero, M., Pansarasa, O., Ceroni, M., Calogero, R. & Cereda, C., Feb 5 2019, In: Scientific data. 6, p. 190006

  Research output: Contribution to journal › Article › peer-review

  • Profiling 100%
  • RNA 85%
  • Blood 78%
  • Lateral 77%
  • Coding 70%